| Mitotane | The serum concentration of Acetaminophen can be decreased when it is combined with Mitotane. | Approved |
| Mitomycin | The serum concentration of Acetaminophen can be increased when it is combined with Mitomycin. | Approved |
| Mirabegron | The serum concentration of Mirabegron can be increased when it is combined with Acetaminophen. | Approved |
| Mipomersen | Acetaminophen may increase the hepatotoxic activities of Mipomersen. | Approved |
| Mifepristone | The serum concentration of Acetaminophen can be increased when it is combined with Mifepristone. | Approved, Investigational |
| Midazolam | The serum concentration of Acetaminophen can be decreased when it is combined with Midazolam. | Approved, Illicit |
| Miconazole | The serum concentration of Acetaminophen can be increased when it is combined with Miconazole. | Approved, Investigational, Vet Approved |
| Mibefradil | The serum concentration of Acetaminophen can be increased when it is combined with Mibefradil. | Withdrawn |
| Mexiletine | The metabolism of Acetaminophen can be decreased when combined with Mexiletine. | Approved |
| Metyrapone | The serum concentration of Acetaminophen can be increased when it is combined with Metyrapone. | Approved |
| Metoprolol | The serum concentration of Metoprolol can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Methylprednisolone | The serum concentration of Methylprednisolone can be increased when it is combined with Acetaminophen. | Approved, Vet Approved |
| Methylphenobarbital | The metabolism of Acetaminophen can be increased when combined with Methylphenobarbital. | Approved |
| Methotrimeprazine | The metabolism of Acetaminophen can be decreased when combined with Methotrimeprazine. | Approved |
| Methotrexate | The serum concentration of Methotrexate can be increased when it is combined with Acetaminophen. | Approved |
| Methohexital | The metabolism of Acetaminophen can be increased when combined with Methohexital. | Approved |
| Methadone | The serum concentration of Acetaminophen can be increased when it is combined with Methadone. | Approved |
| Meprobamate | The serum concentration of Acetaminophen can be increased when it is combined with Meprobamate. | Approved, Illicit |
| Megestrol acetate | The serum concentration of Acetaminophen can be increased when it is combined with Megestrol acetate. | Approved, Vet Approved |
| Mefloquine | The serum concentration of Acetaminophen can be increased when it is combined with Mefloquine. | Approved |
| Mebendazole | The serum concentration of Acetaminophen can be increased when it is combined with Mebendazole. | Approved, Vet Approved |
| Maprotiline | The serum concentration of Acetaminophen can be increased when it is combined with Maprotiline. | Approved |
| Mannitol | The serum concentration of Mannitol can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Lumefantrine | The metabolism of Acetaminophen can be decreased when combined with Lumefantrine. | Approved |
| Lumacaftor | The serum concentration of Acetaminophen can be increased when it is combined with Lumacaftor. | Approved |
| Luliconazole | The serum concentration of Acetaminophen can be increased when it is combined with Luliconazole. | Approved |
| Lovastatin | The metabolism of Acetaminophen can be decreased when combined with Lovastatin. | Approved, Investigational |
| Losartan | The serum concentration of Losartan can be increased when it is combined with Acetaminophen. | Approved |
| Lorcaserin | The metabolism of Acetaminophen can be decreased when combined with Lorcaserin. | Approved |
| Loratadine | The serum concentration of Acetaminophen can be increased when it is combined with Loratadine. | Approved |
| Lopinavir | The metabolism of Acetaminophen can be decreased when combined with Lopinavir. | Approved |
| Loperamide | The serum concentration of Loperamide can be increased when it is combined with Acetaminophen. | Approved |
| Lomitapide | The serum concentration of Acetaminophen can be increased when it is combined with Lomitapide. | Approved |
| Lisinopril | The serum concentration of Acetaminophen can be increased when it is combined with Lisinopril. | Approved, Investigational |
| Liotrix | The serum concentration of Acetaminophen can be decreased when it is combined with Liotrix. | Approved |
| Liothyronine | The serum concentration of Acetaminophen can be decreased when it is combined with Liothyronine. | Approved, Vet Approved |
| Linagliptin | The serum concentration of Linagliptin can be increased when it is combined with Acetaminophen. | Approved |
| Lidocaine | The serum concentration of Acetaminophen can be increased when it is combined with Lidocaine. | Approved, Vet Approved |
| Levothyroxine | The serum concentration of Acetaminophen can be decreased when it is combined with Levothyroxine. | Approved |
| Levomilnacipran | The serum concentration of Levomilnacipran can be increased when it is combined with Acetaminophen. | Approved |
| Levofloxacin | The serum concentration of Levofloxacin can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Levetiracetam | The serum concentration of Levetiracetam can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Lenvatinib | The serum concentration of Lenvatinib can be increased when it is combined with Acetaminophen. | Approved |
| Lenalidomide | The serum concentration of Lenalidomide can be increased when it is combined with Acetaminophen. | Approved |
| Leflunomide | The metabolism of Acetaminophen can be decreased when combined with Leflunomide. | Approved, Investigational |
| Ledipasvir | The serum concentration of Ledipasvir can be increased when it is combined with Acetaminophen. | Approved |
| Lapatinib | The serum concentration of Acetaminophen can be increased when it is combined with Lapatinib. | Approved, Investigational |
| Lansoprazole | The serum concentration of Lansoprazole can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Lamotrigine | The serum concentration of Lamotrigine can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Lamivudine | The serum concentration of Lamivudine can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Ketoconazole | The metabolism of Acetaminophen can be decreased when combined with Ketoconazole. | Approved, Investigational |
| Ketazolam | The serum concentration of Ketazolam can be increased when it is combined with Acetaminophen. | Approved |
| Ketamine | The serum concentration of Acetaminophen can be increased when it is combined with Ketamine. | Approved, Vet Approved |
| Ivermectin | The serum concentration of Ivermectin can be increased when it is combined with Acetaminophen. | Approved, Vet Approved |
| Ivacaftor | The serum concentration of Acetaminophen can be increased when it is combined with Ivacaftor. | Approved |
| Itraconazole | The metabolism of Acetaminophen can be decreased when combined with Itraconazole. | Approved, Investigational |
| Isradipine | The metabolism of Acetaminophen can be decreased when combined with Isradipine. | Approved |
| Isoniazid | The risk or severity of adverse effects can be increased when Isoniazid is combined with Acetaminophen. | Approved |
| Isavuconazonium | The metabolism of Acetaminophen can be decreased when combined with Isavuconazonium. | Approved, Investigational |
| Irinotecan | The serum concentration of Irinotecan can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Irbesartan | The metabolism of Acetaminophen can be decreased when combined with Irbesartan. | Approved, Investigational |
| Indomethacin | The serum concentration of Acetaminophen can be increased when it is combined with Indomethacin. | Approved, Investigational |
| Indinavir | The metabolism of Acetaminophen can be decreased when combined with Indinavir. | Approved |
| Indacaterol | The serum concentration of Indacaterol can be increased when it is combined with Acetaminophen. | Approved |
| Imipramine | The serum concentration of Imipramine can be increased when it is combined with Acetaminophen. | Approved |
| Imatinib | Acetaminophen may increase the hepatotoxic activities of Imatinib. | Approved |
| Idelalisib | The serum concentration of Acetaminophen can be increased when it is combined with Idelalisib. | Approved |
| Ibuprofen | The serum concentration of Ibuprofen can be increased when it is combined with Acetaminophen. | Approved |
| Hydrocortisone | The serum concentration of Hydrocortisone can be increased when it is combined with Acetaminophen. | Approved, Vet Approved |
| Hexobarbital | The metabolism of Acetaminophen can be increased when combined with Hexobarbital. | Approved |
| Haloperidol | The serum concentration of Haloperidol can be increased when it is combined with Acetaminophen. | Approved |
| Grepafloxacin | The serum concentration of Grepafloxacin can be increased when it is combined with Acetaminophen. | Withdrawn |
| Grazoprevir | The serum concentration of Grazoprevir can be increased when it is combined with Acetaminophen. | Approved |
| Gramicidin D | The serum concentration of Acetaminophen can be increased when it is combined with Gramicidin D. | Approved |
| Glycerol | The serum concentration of Acetaminophen can be increased when it is combined with Glycerol. | Experimental |
| Glyburide | The serum concentration of Acetaminophen can be increased when it is combined with Glyburide. | Approved |
| Genistein | The serum concentration of Acetaminophen can be increased when it is combined with Genistein. | Investigational |
| Gemfibrozil | The metabolism of Acetaminophen can be decreased when combined with Gemfibrozil. | Approved |
| Gemcitabine | The serum concentration of Gemcitabine can be increased when it is combined with Acetaminophen. | Approved |
| Gefitinib | The serum concentration of Gefitinib can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Fusidic Acid | The serum concentration of Acetaminophen can be increased when it is combined with Fusidic Acid. | Approved |
| Fosphenytoin | The serum concentration of Acetaminophen can be decreased when it is combined with Fosphenytoin. | Approved |
| Fosaprepitant | The serum concentration of Acetaminophen can be increased when it is combined with Fosaprepitant. | Approved |
| Fosamprenavir | The metabolism of Acetaminophen can be decreased when combined with Fosamprenavir. | Approved |
| Fluvoxamine | The metabolism of Acetaminophen can be decreased when combined with Fluvoxamine. | Approved, Investigational |
| Fluvastatin | The metabolism of Acetaminophen can be decreased when combined with Fluvastatin. | Approved |
| Fluticasone furoate | The serum concentration of Fluticasone furoate can be increased when it is combined with Acetaminophen. | Approved |
| Flurazepam | The serum concentration of Acetaminophen can be increased when it is combined with Flurazepam. | Approved, Illicit |
| Fluphenazine | The serum concentration of Acetaminophen can be increased when it is combined with Fluphenazine. | Approved |
| Flupentixol | The serum concentration of Acetaminophen can be increased when it is combined with Flupentixol. | Approved, Withdrawn |
| Fluoxetine | The metabolism of Acetaminophen can be decreased when combined with Fluoxetine. | Approved, Vet Approved |
| Fluorouracil | The metabolism of Acetaminophen can be decreased when combined with Fluorouracil. | Approved |
| Fluindione | Acetaminophen may increase the anticoagulant activities of Fluindione. | Investigational |
| Fluconazole | The metabolism of Acetaminophen can be decreased when combined with Fluconazole. | Approved |
| Floxuridine | The metabolism of Acetaminophen can be decreased when combined with Floxuridine. | Approved |
| Fidaxomicin | The serum concentration of Fidaxomicin can be increased when it is combined with Acetaminophen. | Approved |
| Fexofenadine | The serum concentration of Fexofenadine can be increased when it is combined with Acetaminophen. | Approved |
| Fesoterodine | The serum concentration of Fesoterodine can be increased when it is combined with Acetaminophen. | Approved |
| Fentanyl | The serum concentration of Acetaminophen can be increased when it is combined with Fentanyl. | Approved, Illicit, Investigational, Vet Approved |
| Felodipine | The serum concentration of Acetaminophen can be increased when it is combined with Felodipine. | Approved, Investigational |