| Mitotane | The serum concentration of Acetaminophen can be decreased when it is combined with Mitotane. | Approved |
| Mitomycin | The serum concentration of Acetaminophen can be increased when it is combined with Mitomycin. | Approved |
| Mirabegron | The serum concentration of Mirabegron can be increased when it is combined with Acetaminophen. | Approved |
| Mipomersen | Acetaminophen may increase the hepatotoxic activities of Mipomersen. | Approved |
| Mifepristone | The serum concentration of Acetaminophen can be increased when it is combined with Mifepristone. | Approved, Investigational |
| Midazolam | The serum concentration of Acetaminophen can be decreased when it is combined with Midazolam. | Approved, Illicit |
| Miconazole | The serum concentration of Acetaminophen can be increased when it is combined with Miconazole. | Approved, Investigational, Vet Approved |
| Mibefradil | The serum concentration of Acetaminophen can be increased when it is combined with Mibefradil. | Withdrawn |
| Mexiletine | The metabolism of Acetaminophen can be decreased when combined with Mexiletine. | Approved |
| Metyrapone | The serum concentration of Acetaminophen can be increased when it is combined with Metyrapone. | Approved |
| Metoprolol | The serum concentration of Metoprolol can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Methylprednisolone | The serum concentration of Methylprednisolone can be increased when it is combined with Acetaminophen. | Approved, Vet Approved |
| Methylphenobarbital | The metabolism of Acetaminophen can be increased when combined with Methylphenobarbital. | Approved |
| Methotrimeprazine | The metabolism of Acetaminophen can be decreased when combined with Methotrimeprazine. | Approved |
| Methotrexate | The serum concentration of Methotrexate can be increased when it is combined with Acetaminophen. | Approved |
| Methohexital | The metabolism of Acetaminophen can be increased when combined with Methohexital. | Approved |
| Methadone | The serum concentration of Acetaminophen can be increased when it is combined with Methadone. | Approved |
| Meprobamate | The serum concentration of Acetaminophen can be increased when it is combined with Meprobamate. | Approved, Illicit |
| Megestrol acetate | The serum concentration of Acetaminophen can be increased when it is combined with Megestrol acetate. | Approved, Vet Approved |
| Mefloquine | The serum concentration of Acetaminophen can be increased when it is combined with Mefloquine. | Approved |
| Mebendazole | The serum concentration of Acetaminophen can be increased when it is combined with Mebendazole. | Approved, Vet Approved |
| Maprotiline | The serum concentration of Acetaminophen can be increased when it is combined with Maprotiline. | Approved |
| Mannitol | The serum concentration of Mannitol can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Lumefantrine | The metabolism of Acetaminophen can be decreased when combined with Lumefantrine. | Approved |
| Lumacaftor | The serum concentration of Acetaminophen can be increased when it is combined with Lumacaftor. | Approved |
| Luliconazole | The serum concentration of Acetaminophen can be increased when it is combined with Luliconazole. | Approved |
| Lovastatin | The metabolism of Acetaminophen can be decreased when combined with Lovastatin. | Approved, Investigational |
| Losartan | The serum concentration of Losartan can be increased when it is combined with Acetaminophen. | Approved |
| Lorcaserin | The metabolism of Acetaminophen can be decreased when combined with Lorcaserin. | Approved |
| Loratadine | The serum concentration of Acetaminophen can be increased when it is combined with Loratadine. | Approved |
| Lopinavir | The metabolism of Acetaminophen can be decreased when combined with Lopinavir. | Approved |
| Loperamide | The serum concentration of Loperamide can be increased when it is combined with Acetaminophen. | Approved |
| Lomitapide | The serum concentration of Acetaminophen can be increased when it is combined with Lomitapide. | Approved |
| Lisinopril | The serum concentration of Acetaminophen can be increased when it is combined with Lisinopril. | Approved, Investigational |
| Liotrix | The serum concentration of Acetaminophen can be decreased when it is combined with Liotrix. | Approved |
| Liothyronine | The serum concentration of Acetaminophen can be decreased when it is combined with Liothyronine. | Approved, Vet Approved |
| Linagliptin | The serum concentration of Linagliptin can be increased when it is combined with Acetaminophen. | Approved |
| Lidocaine | The serum concentration of Acetaminophen can be increased when it is combined with Lidocaine. | Approved, Vet Approved |
| Levothyroxine | The serum concentration of Acetaminophen can be decreased when it is combined with Levothyroxine. | Approved |
| Levomilnacipran | The serum concentration of Levomilnacipran can be increased when it is combined with Acetaminophen. | Approved |
| Levofloxacin | The serum concentration of Levofloxacin can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Levetiracetam | The serum concentration of Levetiracetam can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Lenvatinib | The serum concentration of Lenvatinib can be increased when it is combined with Acetaminophen. | Approved |
| Lenalidomide | The serum concentration of Lenalidomide can be increased when it is combined with Acetaminophen. | Approved |
| Leflunomide | The metabolism of Acetaminophen can be decreased when combined with Leflunomide. | Approved, Investigational |
| Ledipasvir | The serum concentration of Ledipasvir can be increased when it is combined with Acetaminophen. | Approved |
| Lapatinib | The serum concentration of Acetaminophen can be increased when it is combined with Lapatinib. | Approved, Investigational |
| Lansoprazole | The serum concentration of Lansoprazole can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Lamotrigine | The serum concentration of Lamotrigine can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Lamivudine | The serum concentration of Lamivudine can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Ketoconazole | The metabolism of Acetaminophen can be decreased when combined with Ketoconazole. | Approved, Investigational |
| Ketazolam | The serum concentration of Ketazolam can be increased when it is combined with Acetaminophen. | Approved |
| Ketamine | The serum concentration of Acetaminophen can be increased when it is combined with Ketamine. | Approved, Vet Approved |
| Ivermectin | The serum concentration of Ivermectin can be increased when it is combined with Acetaminophen. | Approved, Vet Approved |
| Ivacaftor | The serum concentration of Acetaminophen can be increased when it is combined with Ivacaftor. | Approved |
| Itraconazole | The metabolism of Acetaminophen can be decreased when combined with Itraconazole. | Approved, Investigational |
| Isradipine | The metabolism of Acetaminophen can be decreased when combined with Isradipine. | Approved |
| Isoniazid | The risk or severity of adverse effects can be increased when Isoniazid is combined with Acetaminophen. | Approved |
| Isavuconazonium | The metabolism of Acetaminophen can be decreased when combined with Isavuconazonium. | Approved, Investigational |
| Irinotecan | The serum concentration of Irinotecan can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Irbesartan | The metabolism of Acetaminophen can be decreased when combined with Irbesartan. | Approved, Investigational |
| Indomethacin | The serum concentration of Acetaminophen can be increased when it is combined with Indomethacin. | Approved, Investigational |
| Indinavir | The metabolism of Acetaminophen can be decreased when combined with Indinavir. | Approved |
| Indacaterol | The serum concentration of Indacaterol can be increased when it is combined with Acetaminophen. | Approved |
| Imipramine | The serum concentration of Imipramine can be increased when it is combined with Acetaminophen. | Approved |
| Imatinib | Acetaminophen may increase the hepatotoxic activities of Imatinib. | Approved |
| Idelalisib | The serum concentration of Acetaminophen can be increased when it is combined with Idelalisib. | Approved |
| Ibuprofen | The serum concentration of Ibuprofen can be increased when it is combined with Acetaminophen. | Approved |
| Hydrocortisone | The serum concentration of Hydrocortisone can be increased when it is combined with Acetaminophen. | Approved, Vet Approved |
| Hexobarbital | The metabolism of Acetaminophen can be increased when combined with Hexobarbital. | Approved |
| Haloperidol | The serum concentration of Haloperidol can be increased when it is combined with Acetaminophen. | Approved |
| Grepafloxacin | The serum concentration of Grepafloxacin can be increased when it is combined with Acetaminophen. | Withdrawn |
| Grazoprevir | The serum concentration of Grazoprevir can be increased when it is combined with Acetaminophen. | Approved |
| Gramicidin D | The serum concentration of Acetaminophen can be increased when it is combined with Gramicidin D. | Approved |
| Glycerol | The serum concentration of Acetaminophen can be increased when it is combined with Glycerol. | Experimental |
| Glyburide | The serum concentration of Acetaminophen can be increased when it is combined with Glyburide. | Approved |
| Genistein | The serum concentration of Acetaminophen can be increased when it is combined with Genistein. | Investigational |
| Gemfibrozil | The metabolism of Acetaminophen can be decreased when combined with Gemfibrozil. | Approved |
| Gemcitabine | The serum concentration of Gemcitabine can be increased when it is combined with Acetaminophen. | Approved |
| Gefitinib | The serum concentration of Gefitinib can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Fusidic Acid | The serum concentration of Acetaminophen can be increased when it is combined with Fusidic Acid. | Approved |
| Fosphenytoin | The serum concentration of Acetaminophen can be decreased when it is combined with Fosphenytoin. | Approved |
| Fosaprepitant | The serum concentration of Acetaminophen can be increased when it is combined with Fosaprepitant. | Approved |
| Fosamprenavir | The metabolism of Acetaminophen can be decreased when combined with Fosamprenavir. | Approved |
| Fluvoxamine | The metabolism of Acetaminophen can be decreased when combined with Fluvoxamine. | Approved, Investigational |
| Fluvastatin | The metabolism of Acetaminophen can be decreased when combined with Fluvastatin. | Approved |
| Fluticasone furoate | The serum concentration of Fluticasone furoate can be increased when it is combined with Acetaminophen. | Approved |
| Flurazepam | The serum concentration of Acetaminophen can be increased when it is combined with Flurazepam. | Approved, Illicit |
| Fluphenazine | The serum concentration of Acetaminophen can be increased when it is combined with Fluphenazine. | Approved |
| Flupentixol | The serum concentration of Acetaminophen can be increased when it is combined with Flupentixol. | Approved, Withdrawn |
| Fluoxetine | The metabolism of Acetaminophen can be decreased when combined with Fluoxetine. | Approved, Vet Approved |
| Fluorouracil | The metabolism of Acetaminophen can be decreased when combined with Fluorouracil. | Approved |
| Fluindione | Acetaminophen may increase the anticoagulant activities of Fluindione. | Investigational |
| Fluconazole | The metabolism of Acetaminophen can be decreased when combined with Fluconazole. | Approved |
| Floxuridine | The metabolism of Acetaminophen can be decreased when combined with Floxuridine. | Approved |
| Fidaxomicin | The serum concentration of Fidaxomicin can be increased when it is combined with Acetaminophen. | Approved |
| Fexofenadine | The serum concentration of Fexofenadine can be increased when it is combined with Acetaminophen. | Approved |
| Fesoterodine | The serum concentration of Fesoterodine can be increased when it is combined with Acetaminophen. | Approved |
| Fentanyl | The serum concentration of Acetaminophen can be increased when it is combined with Fentanyl. | Approved, Illicit, Investigational, Vet Approved |
| Felodipine | The serum concentration of Acetaminophen can be increased when it is combined with Felodipine. | Approved, Investigational |
Ziprasidone The metabolism of Acetaminophen can be decreased when combined with Ziprasidone. Approved Zimelidine The serum concentration of Acetaminophen can be increased when it is…
Reserpine The serum concentration of Acetaminophen can be decreased when it is combined with Reserpine. Approved Regorafenib The serum concentration of Acetaminophen can be increased…
Mitotane The serum concentration of Acetaminophen can be decreased when it is combined with Mitotane. Approved Mitomycin The serum concentration of Acetaminophen can be increased…