| Cholic Acid | The serum concentration of Acetaminophen can be decreased when it is combined with Cholic Acid. | Approved |
| Cholestyramine | Cholestyramine can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy. | Approved |
| Cholesterol | The serum concentration of Acetaminophen can be increased when it is combined with Cholesterol. | Experimental |
| Cholecalciferol | The metabolism of Acetaminophen can be decreased when combined with Cholecalciferol. | Approved, Nutraceutical |
| Chlorprothixene | The serum concentration of Acetaminophen can be increased when it is combined with Chlorprothixene. | Approved, Withdrawn |
| Chlorpropamide | The serum concentration of Acetaminophen can be increased when it is combined with Chlorpropamide. | Approved |
| Chlorpromazine | The serum concentration of Acetaminophen can be increased when it is combined with Chlorpromazine. | Approved, Vet Approved |
| Chloroquine | The serum concentration of Acetaminophen can be increased when it is combined with Chloroquine. | Approved, Vet Approved |
| Cerivastatin | The serum concentration of Cerivastatin can be increased when it is combined with Acetaminophen. | Withdrawn |
| Ceritinib | The serum concentration of Acetaminophen can be increased when it is combined with Ceritinib. | Approved |
| Celecoxib | The metabolism of Acetaminophen can be decreased when combined with Celecoxib. | Approved, Investigational |
| Caspofungin | The serum concentration of Acetaminophen can be increased when it is combined with Caspofungin. | Approved |
| Carvedilol | The serum concentration of Acetaminophen can be increased when it is combined with Carvedilol. | Approved, Investigational |
| Carfilzomib | The serum concentration of Carfilzomib can be increased when it is combined with Acetaminophen. | Approved |
| Carbamazepine | The metabolism of Acetaminophen can be increased when combined with Carbamazepine. | Approved, Investigational |
| Captopril | The serum concentration of Acetaminophen can be increased when it is combined with Captopril. | Approved |
| Capecitabine | The metabolism of Acetaminophen can be decreased when combined with Capecitabine. | Approved, Investigational |
| Candesartan | The serum concentration of Acetaminophen can be increased when it is combined with Candesartan. | Approved |
| Canagliflozin | The serum concentration of Canagliflozin can be increased when it is combined with Acetaminophen. | Approved |
| Camptothecin | The serum concentration of Camptothecin can be increased when it is combined with Acetaminophen. | Experimental |
| Caffeine | The serum concentration of Caffeine can be increased when it is combined with Acetaminophen. | Approved |
| Cabazitaxel | The serum concentration of Cabazitaxel can be increased when it is combined with Acetaminophen. | Approved |
| Busulfan | The serum concentration of Busulfan can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Buspirone | The serum concentration of Acetaminophen can be increased when it is combined with Buspirone. | Approved, Investigational |
| Bupropion | The metabolism of Acetaminophen can be decreased when combined with Bupropion. | Approved |
| Buprenorphine | The serum concentration of Acetaminophen can be increased when it is combined with Buprenorphine. | Approved, Illicit, Investigational, Vet Approved |
| Bromocriptine | The serum concentration of Bromocriptine can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Brentuximab vedotin | The serum concentration of Brentuximab vedotin can be increased when it is combined with Acetaminophen. | Approved |
| Bosutinib | The serum concentration of Bosutinib can be increased when it is combined with Acetaminophen. | Approved |
| Bosentan | The serum concentration of Acetaminophen can be decreased when it is combined with Bosentan. | Approved, Investigational |
| Bortezomib | The metabolism of Acetaminophen can be decreased when combined with Bortezomib. | Approved, Investigational |
| Boceprevir | The metabolism of Acetaminophen can be decreased when combined with Boceprevir. | Approved |
| Biperiden | The serum concentration of Acetaminophen can be increased when it is combined with Biperiden. | Approved |
| Bexarotene | The serum concentration of Acetaminophen can be decreased when it is combined with Bexarotene. | Approved, Investigational |
| Betaxolol | The metabolism of Acetaminophen can be decreased when combined with Betaxolol. | Approved |
| Betamethasone | The serum concentration of Betamethasone can be increased when it is combined with Acetaminophen. | Approved, Vet Approved |
| Bepridil | The serum concentration of Acetaminophen can be increased when it is combined with Bepridil. | Approved, Withdrawn |
| Benzocaine | The serum concentration of Acetaminophen can be increased when it is combined with Benzocaine. | Approved |
| Barbital | The metabolism of Acetaminophen can be increased when combined with Barbital. | Illicit |
| Barbexaclone | The metabolism of Acetaminophen can be increased when combined with Barbexaclone. | Experimental |
| Azithromycin | The serum concentration of Acetaminophen can be increased when it is combined with Azithromycin. | Approved |
| Azelastine | The serum concentration of Acetaminophen can be increased when it is combined with Azelastine. | Approved |
| Axitinib | The serum concentration of Axitinib can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Atorvastatin | The serum concentration of Acetaminophen can be increased when it is combined with Atorvastatin. | Approved |
| Atomoxetine | The metabolism of Acetaminophen can be decreased when combined with Atomoxetine. | Approved |
| Atenolol | The serum concentration of Atenolol can be increased when it is combined with Acetaminophen. | Approved |
| Atazanavir | The metabolism of Acetaminophen can be decreased when combined with Atazanavir. | Approved, Investigational |
| Astemizole | The serum concentration of Acetaminophen can be increased when it is combined with Astemizole. | Approved, Withdrawn |
| Artemether | The metabolism of Acetaminophen can be decreased when combined with Artemether. | Approved |
| Arsenic trioxide | The serum concentration of Arsenic trioxide can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Aripiprazole | The serum concentration of Aripiprazole can be decreased when it is combined with Acetaminophen. | Approved, Investigational |
| Aprepitant | The serum concentration of Acetaminophen can be increased when it is combined with Aprepitant. | Approved, Investigational |
| Apixaban | The serum concentration of Apixaban can be increased when it is combined with Acetaminophen. | Approved |
| Amsacrine | The serum concentration of Acetaminophen can be increased when it is combined with Amsacrine. | Approved |
| Amprenavir | The serum concentration of Acetaminophen can be decreased when it is combined with Amprenavir. | Approved |
| Amobarbital | The metabolism of Acetaminophen can be increased when combined with Amobarbital. | Approved, Illicit |
| Amlodipine | The serum concentration of Acetaminophen can be increased when it is combined with Amlodipine. | Approved |
| Amitriptyline | The serum concentration of Amitriptyline can be increased when it is combined with Acetaminophen. | Approved |
| Amiodarone | The metabolism of Acetaminophen can be decreased when combined with Amiodarone. | Approved, Investigational |
| Aminohippuric acid | The serum concentration of Acetaminophen can be increased when it is combined with Aminohippuric acid. | Approved |
| Ambrisentan | The serum concentration of Ambrisentan can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Amantadine | The serum concentration of Acetaminophen can be increased when it is combined with Amantadine. | Approved |
| Alitretinoin | The serum concentration of Alitretinoin can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Alfentanil | The serum concentration of Acetaminophen can be increased when it is combined with Alfentanil. | Approved, Illicit |
| Alectinib | The serum concentration of Acetaminophen can be increased when it is combined with Alectinib. | Approved |
| Aldosterone | The serum concentration of Acetaminophen can be decreased when it is combined with Aldosterone. | Experimental |
| Albendazole | The serum concentration of Acetaminophen can be increased when it is combined with Albendazole. | Approved, Vet Approved |
| Afatinib | The serum concentration of Afatinib can be increased when it is combined with Acetaminophen. | Approved |
| Acetylsalicylic acid | The serum concentration of Acetylsalicylic acid can be increased when it is combined with Acetaminophen. | Approved, Vet Approved |
| Acenocoumarol | Acetaminophen may increase the anticoagulant activities of Acenocoumarol. | Approved |
| Acebutolol | The serum concentration of Acebutolol can be increased when it is combined with Acetaminophen. | Approved |
| Abiraterone | The serum concentration of Acetaminophen can be increased when it is combined with Abiraterone. | Approved |