| Cholic Acid | The serum concentration of Acetaminophen can be decreased when it is combined with Cholic Acid. | Approved |
| Cholestyramine | Cholestyramine can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy. | Approved |
| Cholesterol | The serum concentration of Acetaminophen can be increased when it is combined with Cholesterol. | Experimental |
| Cholecalciferol | The metabolism of Acetaminophen can be decreased when combined with Cholecalciferol. | Approved, Nutraceutical |
| Chlorprothixene | The serum concentration of Acetaminophen can be increased when it is combined with Chlorprothixene. | Approved, Withdrawn |
| Chlorpropamide | The serum concentration of Acetaminophen can be increased when it is combined with Chlorpropamide. | Approved |
| Chlorpromazine | The serum concentration of Acetaminophen can be increased when it is combined with Chlorpromazine. | Approved, Vet Approved |
| Chloroquine | The serum concentration of Acetaminophen can be increased when it is combined with Chloroquine. | Approved, Vet Approved |
| Cerivastatin | The serum concentration of Cerivastatin can be increased when it is combined with Acetaminophen. | Withdrawn |
| Ceritinib | The serum concentration of Acetaminophen can be increased when it is combined with Ceritinib. | Approved |
| Celecoxib | The metabolism of Acetaminophen can be decreased when combined with Celecoxib. | Approved, Investigational |
| Caspofungin | The serum concentration of Acetaminophen can be increased when it is combined with Caspofungin. | Approved |
| Carvedilol | The serum concentration of Acetaminophen can be increased when it is combined with Carvedilol. | Approved, Investigational |
| Carfilzomib | The serum concentration of Carfilzomib can be increased when it is combined with Acetaminophen. | Approved |
| Carbamazepine | The metabolism of Acetaminophen can be increased when combined with Carbamazepine. | Approved, Investigational |
| Captopril | The serum concentration of Acetaminophen can be increased when it is combined with Captopril. | Approved |
| Capecitabine | The metabolism of Acetaminophen can be decreased when combined with Capecitabine. | Approved, Investigational |
| Candesartan | The serum concentration of Acetaminophen can be increased when it is combined with Candesartan. | Approved |
| Canagliflozin | The serum concentration of Canagliflozin can be increased when it is combined with Acetaminophen. | Approved |
| Camptothecin | The serum concentration of Camptothecin can be increased when it is combined with Acetaminophen. | Experimental |
| Caffeine | The serum concentration of Caffeine can be increased when it is combined with Acetaminophen. | Approved |
| Cabazitaxel | The serum concentration of Cabazitaxel can be increased when it is combined with Acetaminophen. | Approved |
| Busulfan | The serum concentration of Busulfan can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Buspirone | The serum concentration of Acetaminophen can be increased when it is combined with Buspirone. | Approved, Investigational |
| Bupropion | The metabolism of Acetaminophen can be decreased when combined with Bupropion. | Approved |
| Buprenorphine | The serum concentration of Acetaminophen can be increased when it is combined with Buprenorphine. | Approved, Illicit, Investigational, Vet Approved |
| Bromocriptine | The serum concentration of Bromocriptine can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Brentuximab vedotin | The serum concentration of Brentuximab vedotin can be increased when it is combined with Acetaminophen. | Approved |
| Bosutinib | The serum concentration of Bosutinib can be increased when it is combined with Acetaminophen. | Approved |
| Bosentan | The serum concentration of Acetaminophen can be decreased when it is combined with Bosentan. | Approved, Investigational |
| Bortezomib | The metabolism of Acetaminophen can be decreased when combined with Bortezomib. | Approved, Investigational |
| Boceprevir | The metabolism of Acetaminophen can be decreased when combined with Boceprevir. | Approved |
| Biperiden | The serum concentration of Acetaminophen can be increased when it is combined with Biperiden. | Approved |
| Bexarotene | The serum concentration of Acetaminophen can be decreased when it is combined with Bexarotene. | Approved, Investigational |
| Betaxolol | The metabolism of Acetaminophen can be decreased when combined with Betaxolol. | Approved |
| Betamethasone | The serum concentration of Betamethasone can be increased when it is combined with Acetaminophen. | Approved, Vet Approved |
| Bepridil | The serum concentration of Acetaminophen can be increased when it is combined with Bepridil. | Approved, Withdrawn |
| Benzocaine | The serum concentration of Acetaminophen can be increased when it is combined with Benzocaine. | Approved |
| Barbital | The metabolism of Acetaminophen can be increased when combined with Barbital. | Illicit |
| Barbexaclone | The metabolism of Acetaminophen can be increased when combined with Barbexaclone. | Experimental |
| Azithromycin | The serum concentration of Acetaminophen can be increased when it is combined with Azithromycin. | Approved |
| Azelastine | The serum concentration of Acetaminophen can be increased when it is combined with Azelastine. | Approved |
| Axitinib | The serum concentration of Axitinib can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Atorvastatin | The serum concentration of Acetaminophen can be increased when it is combined with Atorvastatin. | Approved |
| Atomoxetine | The metabolism of Acetaminophen can be decreased when combined with Atomoxetine. | Approved |
| Atenolol | The serum concentration of Atenolol can be increased when it is combined with Acetaminophen. | Approved |
| Atazanavir | The metabolism of Acetaminophen can be decreased when combined with Atazanavir. | Approved, Investigational |
| Astemizole | The serum concentration of Acetaminophen can be increased when it is combined with Astemizole. | Approved, Withdrawn |
| Artemether | The metabolism of Acetaminophen can be decreased when combined with Artemether. | Approved |
| Arsenic trioxide | The serum concentration of Arsenic trioxide can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Aripiprazole | The serum concentration of Aripiprazole can be decreased when it is combined with Acetaminophen. | Approved, Investigational |
| Aprepitant | The serum concentration of Acetaminophen can be increased when it is combined with Aprepitant. | Approved, Investigational |
| Apixaban | The serum concentration of Apixaban can be increased when it is combined with Acetaminophen. | Approved |
| Amsacrine | The serum concentration of Acetaminophen can be increased when it is combined with Amsacrine. | Approved |
| Amprenavir | The serum concentration of Acetaminophen can be decreased when it is combined with Amprenavir. | Approved |
| Amobarbital | The metabolism of Acetaminophen can be increased when combined with Amobarbital. | Approved, Illicit |
| Amlodipine | The serum concentration of Acetaminophen can be increased when it is combined with Amlodipine. | Approved |
| Amitriptyline | The serum concentration of Amitriptyline can be increased when it is combined with Acetaminophen. | Approved |
| Amiodarone | The metabolism of Acetaminophen can be decreased when combined with Amiodarone. | Approved, Investigational |
| Aminohippuric acid | The serum concentration of Acetaminophen can be increased when it is combined with Aminohippuric acid. | Approved |
| Ambrisentan | The serum concentration of Ambrisentan can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Amantadine | The serum concentration of Acetaminophen can be increased when it is combined with Amantadine. | Approved |
| Alitretinoin | The serum concentration of Alitretinoin can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Alfentanil | The serum concentration of Acetaminophen can be increased when it is combined with Alfentanil. | Approved, Illicit |
| Alectinib | The serum concentration of Acetaminophen can be increased when it is combined with Alectinib. | Approved |
| Aldosterone | The serum concentration of Acetaminophen can be decreased when it is combined with Aldosterone. | Experimental |
| Albendazole | The serum concentration of Acetaminophen can be increased when it is combined with Albendazole. | Approved, Vet Approved |
| Afatinib | The serum concentration of Afatinib can be increased when it is combined with Acetaminophen. | Approved |
| Acetylsalicylic acid | The serum concentration of Acetylsalicylic acid can be increased when it is combined with Acetaminophen. | Approved, Vet Approved |
| Acenocoumarol | Acetaminophen may increase the anticoagulant activities of Acenocoumarol. | Approved |
| Acebutolol | The serum concentration of Acebutolol can be increased when it is combined with Acetaminophen. | Approved |
| Abiraterone | The serum concentration of Acetaminophen can be increased when it is combined with Abiraterone. | Approved |
Ziprasidone The metabolism of Acetaminophen can be decreased when combined with Ziprasidone. Approved Zimelidine The serum concentration of Acetaminophen can be increased when it is…
Reserpine The serum concentration of Acetaminophen can be decreased when it is combined with Reserpine. Approved Regorafenib The serum concentration of Acetaminophen can be increased…
Mitotane The serum concentration of Acetaminophen can be decreased when it is combined with Mitotane. Approved Mitomycin The serum concentration of Acetaminophen can be increased…