| Ziprasidone | The metabolism of Acetaminophen can be decreased when combined with Ziprasidone. | Approved |
| Zimelidine | The serum concentration of Acetaminophen can be increased when it is combined with Zimelidine. | Withdrawn |
| Zidovudine | The serum concentration of Zidovudine can be increased when it is combined with Acetaminophen. | Approved |
| Zafirlukast | The metabolism of Acetaminophen can be decreased when combined with Zafirlukast. | Approved, Investigational |
| Warfarin | Acetaminophen may increase the anticoagulant activities of Warfarin. | Approved |
| Voriconazole | The metabolism of Acetaminophen can be decreased when combined with Voriconazole. | Approved, Investigational |
| Vismodegib | The serum concentration of Vismodegib can be increased when it is combined with Acetaminophen. | Approved |
| Vinorelbine | The serum concentration of Acetaminophen can be increased when it is combined with Vinorelbine. | Approved, Investigational |
| Vincristine | The serum concentration of Vincristine can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Vincristine | The serum concentration of Acetaminophen can be decreased when it is combined with Vincristine. | Approved, Investigational |
| Vinblastine | The serum concentration of Acetaminophen can be decreased when it is combined with Vinblastine. | Approved |
| Verapamil | The metabolism of Acetaminophen can be decreased when combined with Verapamil. | Approved |
| Venlafaxine | The metabolism of Acetaminophen can be decreased when combined with Venlafaxine. | Approved |
| Venetoclax | The serum concentration of Venetoclax can be increased when it is combined with Acetaminophen. | Approved |
| Vemurafenib | The serum concentration of Acetaminophen can be increased when it is combined with Vemurafenib. | Approved |
| Vecuronium | The serum concentration of Vecuronium can be increased when it is combined with Acetaminophen. | Approved |
| Valsartan | The metabolism of Acetaminophen can be decreased when combined with Valsartan. | Approved, Investigational |
| Valproic Acid | The metabolism of Acetaminophen can be decreased when combined with Valproic Acid. | Approved, Investigational |
| Umeclidinium | The serum concentration of Umeclidinium can be increased when it is combined with Acetaminophen. | Approved |
| Ulipristal | The serum concentration of Ulipristal can be increased when it is combined with Acetaminophen. | Approved |
| Troleandomycin | The serum concentration of Acetaminophen can be increased when it is combined with Troleandomycin. | Approved |
| Trimipramine | The serum concentration of Acetaminophen can be increased when it is combined with Trimipramine. | Approved |
| Trimethoprim | The serum concentration of Acetaminophen can be decreased when it is combined with Trimethoprim. | Approved, Vet Approved |
| Triflupromazine | The serum concentration of Acetaminophen can be increased when it is combined with Triflupromazine. | Approved, Vet Approved |
| Trifluoperazine | The serum concentration of Acetaminophen can be increased when it is combined with Trifluoperazine. | Approved |
| Trazodone | The serum concentration of Acetaminophen can be decreased when it is combined with Trazodone. | Approved, Investigational |
| Trastuzumab emtansine | The serum concentration of Trastuzumab emtansine can be increased when it is combined with Acetaminophen. | Approved |
| Tranylcypromine | The metabolism of Acetaminophen can be decreased when combined with Tranylcypromine. | Approved |
| Toremifene | The serum concentration of Toremifene can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Topotecan | The serum concentration of Topotecan can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Tolvaptan | The serum concentration of Tolvaptan can be increased when it is combined with Acetaminophen. | Approved |
| Tolbutamide | The metabolism of Acetaminophen can be decreased when combined with Tolbutamide. | Approved |
| Tocilizumab | The serum concentration of Acetaminophen can be decreased when it is combined with Tocilizumab. | Approved |
| Tipranavir | The metabolism of Acetaminophen can be decreased when combined with Tipranavir. | Approved, Investigational |
| Timolol | The serum concentration of Timolol can be increased when it is combined with Acetaminophen. | Approved |
| Ticlopidine | The metabolism of Acetaminophen can be decreased when combined with Ticlopidine. | Approved |
| Ticagrelor | The serum concentration of Ticagrelor can be increased when it is combined with Acetaminophen. | Approved |
| Thioridazine | The metabolism of Acetaminophen can be decreased when combined with Thioridazine. | Approved |
| Thiopental | The metabolism of Acetaminophen can be increased when combined with Thiopental. | Approved, Vet Approved |
| Thiamylal | The metabolism of Acetaminophen can be increased when combined with Thiamylal. | Approved, Vet Approved |
| Theophylline | The metabolism of Acetaminophen can be decreased when combined with Theophylline. | Approved |
| Testosterone | The serum concentration of Acetaminophen can be increased when it is combined with Testosterone. | Approved, Investigational |
| Tesmilifene | The serum concentration of Acetaminophen can be decreased when it is combined with Tesmilifene. | Investigational |
| Teriflunomide | The serum concentration of Acetaminophen can be decreased when it is combined with Teriflunomide. | Approved |
| Terfenadine | The serum concentration of Acetaminophen can be increased when it is combined with Terfenadine. | Withdrawn |
| Terbinafine | The metabolism of Acetaminophen can be decreased when combined with Terbinafine. | Approved, Investigational, Vet Approved |
| Terazosin | The serum concentration of Acetaminophen can be increased when it is combined with Terazosin. | Approved |
| Tenofovir | The metabolism of Acetaminophen can be decreased when combined with Tenofovir. | Approved, Investigational |
| Temsirolimus | The serum concentration of Temsirolimus can be increased when it is combined with Acetaminophen. | Approved |
| Telmisartan | The serum concentration of Acetaminophen can be increased when it is combined with Telmisartan. | Approved, Investigational |
| Telithromycin | The metabolism of Acetaminophen can be decreased when combined with Telithromycin. | Approved |
| Telaprevir | The metabolism of Acetaminophen can be decreased when combined with Telaprevir. | Approved |
| Technetium Tc-99m sestamibi | The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Acetaminophen. | Approved |
| Taurocholic Acid | The serum concentration of Taurocholic Acid can be increased when it is combined with Acetaminophen. | Experimental |
| Tamoxifen | The serum concentration of Acetaminophen can be decreased when it is combined with Tamoxifen. | Approved |
| Tacrolimus | The serum concentration of Acetaminophen can be decreased when it is combined with Tacrolimus. | Approved, Investigational |
| Tacrine | The serum concentration of Acetaminophen can be increased when it is combined with Tacrine. | Withdrawn |
| Sunitinib | The serum concentration of Acetaminophen can be increased when it is combined with Sunitinib. | Approved, Investigational |
| Sumatriptan | The serum concentration of Acetaminophen can be increased when it is combined with Sumatriptan. | Approved, Investigational |
| Sulfisoxazole | The metabolism of Acetaminophen can be decreased when combined with Sulfisoxazole. | Approved, Vet Approved |
| Sulfinpyrazone | The serum concentration of Acetaminophen can be increased when it is combined with Sulfinpyrazone. | Approved |
| Sulfamethoxazole | The metabolism of Acetaminophen can be decreased when combined with Sulfamethoxazole. | Approved |
| Sulfadiazine | The metabolism of Acetaminophen can be decreased when combined with Sulfadiazine. | Approved, Vet Approved |
| Streptozocin | The serum concentration of Acetaminophen can be decreased when it is combined with Streptozocin. | Approved |
| Stiripentol | The serum concentration of Acetaminophen can be increased when it is combined with Stiripentol. | Approved |
| Staurosporine | The serum concentration of Acetaminophen can be increased when it is combined with Staurosporine. | Experimental |
| St. John’s Wort | The serum concentration of Acetaminophen can be decreased when it is combined with St. John's Wort. | Nutraceutical |
| Spironolactone | The serum concentration of Acetaminophen can be increased when it is combined with Spironolactone. | Approved |
| Sphingosine | The serum concentration of Sphingosine can be increased when it is combined with Acetaminophen. | Experimental |
| Sparfloxacin | The serum concentration of Sparfloxacin can be increased when it is combined with Acetaminophen. | Approved |
| Sorafenib | Acetaminophen may increase the hepatotoxic activities of Sorafenib. | Approved, Investigational |
| Sofosbuvir | The serum concentration of Sofosbuvir can be increased when it is combined with Acetaminophen. | Approved |
| Sodium Nitrite | The risk or severity of adverse effects can be increased when Acetaminophen is combined with Sodium Nitrite. | Approved |
| Sitagliptin | The serum concentration of Sitagliptin can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Sirolimus | The serum concentration of Acetaminophen can be decreased when it is combined with Sirolimus. | Approved, Investigational |
| Simvastatin | The serum concentration of Acetaminophen can be increased when it is combined with Simvastatin. | Approved |
| Simeprevir | The serum concentration of Acetaminophen can be increased when it is combined with Simeprevir. | Approved |
| Siltuximab | The serum concentration of Acetaminophen can be decreased when it is combined with Siltuximab. | Approved |
| Silodosin | The serum concentration of Silodosin can be increased when it is combined with Acetaminophen. | Approved |
| Sildenafil | The metabolism of Acetaminophen can be decreased when combined with Sildenafil. | Approved, Investigational |
| Sertraline | The serum concentration of Acetaminophen can be increased when it is combined with Sertraline. | Approved |
| Selexipag | The serum concentration of Selexipag can be increased when it is combined with Acetaminophen. | Approved |
| Selegiline | The serum concentration of Acetaminophen can be increased when it is combined with Selegiline. | Approved, Investigational, Vet Approved |
| Secobarbital | The metabolism of Acetaminophen can be increased when combined with Secobarbital. | Approved, Vet Approved |
| Scopolamine | The serum concentration of Acetaminophen can be increased when it is combined with Scopolamine. | Approved |
| Saxagliptin | The serum concentration of Saxagliptin can be decreased when it is combined with Acetaminophen. | Approved |
| Saquinavir | The metabolism of Acetaminophen can be decreased when combined with Saquinavir. | Approved, Investigational |
| Salicylic acid | The serum concentration of Salicylic acid can be increased when it is combined with Acetaminophen. | Approved, Vet Approved |
| Rosiglitazone | The metabolism of Acetaminophen can be decreased when combined with Rosiglitazone. | Approved, Investigational |
| Ropinirole | The metabolism of Acetaminophen can be decreased when combined with Ropinirole. | Approved, Investigational |
| Romidepsin | The serum concentration of Romidepsin can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Rolapitant | The serum concentration of Acetaminophen can be increased when it is combined with Rolapitant. | Approved |
| Rivaroxaban | The serum concentration of Rivaroxaban can be increased when it is combined with Acetaminophen. | Approved |
| Ritonavir | The metabolism of Acetaminophen can be decreased when combined with Ritonavir. | Approved, Investigational |
| Risperidone | The serum concentration of Risperidone can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Rilpivirine | The serum concentration of Acetaminophen can be increased when it is combined with Rilpivirine. | Approved |
| Rifaximin | The serum concentration of Rifaximin can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Rifapentine | The metabolism of Acetaminophen can be increased when combined with Rifapentine. | Approved |
| Rifampicin | The metabolism of Acetaminophen can be increased when combined with Rifampicin. | Approved |
| Rifabutin | The metabolism of Acetaminophen can be increased when combined with Rifabutin. | Approved |