| Ziprasidone | The metabolism of Acetaminophen can be decreased when combined with Ziprasidone. | Approved |
| Zimelidine | The serum concentration of Acetaminophen can be increased when it is combined with Zimelidine. | Withdrawn |
| Zidovudine | The serum concentration of Zidovudine can be increased when it is combined with Acetaminophen. | Approved |
| Zafirlukast | The metabolism of Acetaminophen can be decreased when combined with Zafirlukast. | Approved, Investigational |
| Warfarin | Acetaminophen may increase the anticoagulant activities of Warfarin. | Approved |
| Voriconazole | The metabolism of Acetaminophen can be decreased when combined with Voriconazole. | Approved, Investigational |
| Vismodegib | The serum concentration of Vismodegib can be increased when it is combined with Acetaminophen. | Approved |
| Vinorelbine | The serum concentration of Acetaminophen can be increased when it is combined with Vinorelbine. | Approved, Investigational |
| Vincristine | The serum concentration of Vincristine can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Vincristine | The serum concentration of Acetaminophen can be decreased when it is combined with Vincristine. | Approved, Investigational |
| Vinblastine | The serum concentration of Acetaminophen can be decreased when it is combined with Vinblastine. | Approved |
| Verapamil | The metabolism of Acetaminophen can be decreased when combined with Verapamil. | Approved |
| Venlafaxine | The metabolism of Acetaminophen can be decreased when combined with Venlafaxine. | Approved |
| Venetoclax | The serum concentration of Venetoclax can be increased when it is combined with Acetaminophen. | Approved |
| Vemurafenib | The serum concentration of Acetaminophen can be increased when it is combined with Vemurafenib. | Approved |
| Vecuronium | The serum concentration of Vecuronium can be increased when it is combined with Acetaminophen. | Approved |
| Valsartan | The metabolism of Acetaminophen can be decreased when combined with Valsartan. | Approved, Investigational |
| Valproic Acid | The metabolism of Acetaminophen can be decreased when combined with Valproic Acid. | Approved, Investigational |
| Umeclidinium | The serum concentration of Umeclidinium can be increased when it is combined with Acetaminophen. | Approved |
| Ulipristal | The serum concentration of Ulipristal can be increased when it is combined with Acetaminophen. | Approved |
| Troleandomycin | The serum concentration of Acetaminophen can be increased when it is combined with Troleandomycin. | Approved |
| Trimipramine | The serum concentration of Acetaminophen can be increased when it is combined with Trimipramine. | Approved |
| Trimethoprim | The serum concentration of Acetaminophen can be decreased when it is combined with Trimethoprim. | Approved, Vet Approved |
| Triflupromazine | The serum concentration of Acetaminophen can be increased when it is combined with Triflupromazine. | Approved, Vet Approved |
| Trifluoperazine | The serum concentration of Acetaminophen can be increased when it is combined with Trifluoperazine. | Approved |
| Trazodone | The serum concentration of Acetaminophen can be decreased when it is combined with Trazodone. | Approved, Investigational |
| Trastuzumab emtansine | The serum concentration of Trastuzumab emtansine can be increased when it is combined with Acetaminophen. | Approved |
| Tranylcypromine | The metabolism of Acetaminophen can be decreased when combined with Tranylcypromine. | Approved |
| Toremifene | The serum concentration of Toremifene can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Topotecan | The serum concentration of Topotecan can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Tolvaptan | The serum concentration of Tolvaptan can be increased when it is combined with Acetaminophen. | Approved |
| Tolbutamide | The metabolism of Acetaminophen can be decreased when combined with Tolbutamide. | Approved |
| Tocilizumab | The serum concentration of Acetaminophen can be decreased when it is combined with Tocilizumab. | Approved |
| Tipranavir | The metabolism of Acetaminophen can be decreased when combined with Tipranavir. | Approved, Investigational |
| Timolol | The serum concentration of Timolol can be increased when it is combined with Acetaminophen. | Approved |
| Ticlopidine | The metabolism of Acetaminophen can be decreased when combined with Ticlopidine. | Approved |
| Ticagrelor | The serum concentration of Ticagrelor can be increased when it is combined with Acetaminophen. | Approved |
| Thioridazine | The metabolism of Acetaminophen can be decreased when combined with Thioridazine. | Approved |
| Thiopental | The metabolism of Acetaminophen can be increased when combined with Thiopental. | Approved, Vet Approved |
| Thiamylal | The metabolism of Acetaminophen can be increased when combined with Thiamylal. | Approved, Vet Approved |
| Theophylline | The metabolism of Acetaminophen can be decreased when combined with Theophylline. | Approved |
| Testosterone | The serum concentration of Acetaminophen can be increased when it is combined with Testosterone. | Approved, Investigational |
| Tesmilifene | The serum concentration of Acetaminophen can be decreased when it is combined with Tesmilifene. | Investigational |
| Teriflunomide | The serum concentration of Acetaminophen can be decreased when it is combined with Teriflunomide. | Approved |
| Terfenadine | The serum concentration of Acetaminophen can be increased when it is combined with Terfenadine. | Withdrawn |
| Terbinafine | The metabolism of Acetaminophen can be decreased when combined with Terbinafine. | Approved, Investigational, Vet Approved |
| Terazosin | The serum concentration of Acetaminophen can be increased when it is combined with Terazosin. | Approved |
| Tenofovir | The metabolism of Acetaminophen can be decreased when combined with Tenofovir. | Approved, Investigational |
| Temsirolimus | The serum concentration of Temsirolimus can be increased when it is combined with Acetaminophen. | Approved |
| Telmisartan | The serum concentration of Acetaminophen can be increased when it is combined with Telmisartan. | Approved, Investigational |
| Telithromycin | The metabolism of Acetaminophen can be decreased when combined with Telithromycin. | Approved |
| Telaprevir | The metabolism of Acetaminophen can be decreased when combined with Telaprevir. | Approved |
| Technetium Tc-99m sestamibi | The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Acetaminophen. | Approved |
| Taurocholic Acid | The serum concentration of Taurocholic Acid can be increased when it is combined with Acetaminophen. | Experimental |
| Tamoxifen | The serum concentration of Acetaminophen can be decreased when it is combined with Tamoxifen. | Approved |
| Tacrolimus | The serum concentration of Acetaminophen can be decreased when it is combined with Tacrolimus. | Approved, Investigational |
| Tacrine | The serum concentration of Acetaminophen can be increased when it is combined with Tacrine. | Withdrawn |
| Sunitinib | The serum concentration of Acetaminophen can be increased when it is combined with Sunitinib. | Approved, Investigational |
| Sumatriptan | The serum concentration of Acetaminophen can be increased when it is combined with Sumatriptan. | Approved, Investigational |
| Sulfisoxazole | The metabolism of Acetaminophen can be decreased when combined with Sulfisoxazole. | Approved, Vet Approved |
| Sulfinpyrazone | The serum concentration of Acetaminophen can be increased when it is combined with Sulfinpyrazone. | Approved |
| Sulfamethoxazole | The metabolism of Acetaminophen can be decreased when combined with Sulfamethoxazole. | Approved |
| Sulfadiazine | The metabolism of Acetaminophen can be decreased when combined with Sulfadiazine. | Approved, Vet Approved |
| Streptozocin | The serum concentration of Acetaminophen can be decreased when it is combined with Streptozocin. | Approved |
| Stiripentol | The serum concentration of Acetaminophen can be increased when it is combined with Stiripentol. | Approved |
| Staurosporine | The serum concentration of Acetaminophen can be increased when it is combined with Staurosporine. | Experimental |
| St. John’s Wort | The serum concentration of Acetaminophen can be decreased when it is combined with St. John's Wort. | Nutraceutical |
| Spironolactone | The serum concentration of Acetaminophen can be increased when it is combined with Spironolactone. | Approved |
| Sphingosine | The serum concentration of Sphingosine can be increased when it is combined with Acetaminophen. | Experimental |
| Sparfloxacin | The serum concentration of Sparfloxacin can be increased when it is combined with Acetaminophen. | Approved |
| Sorafenib | Acetaminophen may increase the hepatotoxic activities of Sorafenib. | Approved, Investigational |
| Sofosbuvir | The serum concentration of Sofosbuvir can be increased when it is combined with Acetaminophen. | Approved |
| Sodium Nitrite | The risk or severity of adverse effects can be increased when Acetaminophen is combined with Sodium Nitrite. | Approved |
| Sitagliptin | The serum concentration of Sitagliptin can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Sirolimus | The serum concentration of Acetaminophen can be decreased when it is combined with Sirolimus. | Approved, Investigational |
| Simvastatin | The serum concentration of Acetaminophen can be increased when it is combined with Simvastatin. | Approved |
| Simeprevir | The serum concentration of Acetaminophen can be increased when it is combined with Simeprevir. | Approved |
| Siltuximab | The serum concentration of Acetaminophen can be decreased when it is combined with Siltuximab. | Approved |
| Silodosin | The serum concentration of Silodosin can be increased when it is combined with Acetaminophen. | Approved |
| Sildenafil | The metabolism of Acetaminophen can be decreased when combined with Sildenafil. | Approved, Investigational |
| Sertraline | The serum concentration of Acetaminophen can be increased when it is combined with Sertraline. | Approved |
| Selexipag | The serum concentration of Selexipag can be increased when it is combined with Acetaminophen. | Approved |
| Selegiline | The serum concentration of Acetaminophen can be increased when it is combined with Selegiline. | Approved, Investigational, Vet Approved |
| Secobarbital | The metabolism of Acetaminophen can be increased when combined with Secobarbital. | Approved, Vet Approved |
| Scopolamine | The serum concentration of Acetaminophen can be increased when it is combined with Scopolamine. | Approved |
| Saxagliptin | The serum concentration of Saxagliptin can be decreased when it is combined with Acetaminophen. | Approved |
| Saquinavir | The metabolism of Acetaminophen can be decreased when combined with Saquinavir. | Approved, Investigational |
| Salicylic acid | The serum concentration of Salicylic acid can be increased when it is combined with Acetaminophen. | Approved, Vet Approved |
| Rosiglitazone | The metabolism of Acetaminophen can be decreased when combined with Rosiglitazone. | Approved, Investigational |
| Ropinirole | The metabolism of Acetaminophen can be decreased when combined with Ropinirole. | Approved, Investigational |
| Romidepsin | The serum concentration of Romidepsin can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Rolapitant | The serum concentration of Acetaminophen can be increased when it is combined with Rolapitant. | Approved |
| Rivaroxaban | The serum concentration of Rivaroxaban can be increased when it is combined with Acetaminophen. | Approved |
| Ritonavir | The metabolism of Acetaminophen can be decreased when combined with Ritonavir. | Approved, Investigational |
| Risperidone | The serum concentration of Risperidone can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Rilpivirine | The serum concentration of Acetaminophen can be increased when it is combined with Rilpivirine. | Approved |
| Rifaximin | The serum concentration of Rifaximin can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Rifapentine | The metabolism of Acetaminophen can be increased when combined with Rifapentine. | Approved |
| Rifampicin | The metabolism of Acetaminophen can be increased when combined with Rifampicin. | Approved |
| Rifabutin | The metabolism of Acetaminophen can be increased when combined with Rifabutin. | Approved |
Ziprasidone The metabolism of Acetaminophen can be decreased when combined with Ziprasidone. Approved Zimelidine The serum concentration of Acetaminophen can be increased when it is…
Reserpine The serum concentration of Acetaminophen can be decreased when it is combined with Reserpine. Approved Regorafenib The serum concentration of Acetaminophen can be increased…
Mitotane The serum concentration of Acetaminophen can be decreased when it is combined with Mitotane. Approved Mitomycin The serum concentration of Acetaminophen can be increased…