| Ezetimibe | The serum concentration of Ezetimibe can be increased when it is combined with Acetaminophen. | Approved |
| Everolimus | The serum concentration of Everolimus can be increased when it is combined with Acetaminophen. | Approved |
| Etravirine | The serum concentration of Acetaminophen can be decreased when it is combined with Etravirine. | Approved |
| Etoposide | The serum concentration of Acetaminophen can be increased when it is combined with Etoposide. | Approved |
| Ethyl biscoumacetate | Acetaminophen may increase the anticoagulant activities of Ethyl biscoumacetate. | Withdrawn |
| Ethinyl Estradiol | The serum concentration of Ethinyl Estradiol can be increased when it is combined with Acetaminophen. | Approved |
| Ethanol | Ethanol may increase the hepatotoxic activities of Acetaminophen. | Approved |
| Estrone | The serum concentration of Acetaminophen can be decreased when it is combined with Estrone. | Approved |
| Estriol | The serum concentration of Acetaminophen can be decreased when it is combined with Estriol. | Approved, Vet Approved |
| Estramustine | The serum concentration of Acetaminophen can be increased when it is combined with Estramustine. | Approved |
| Estradiol | The serum concentration of Estradiol can be increased when it is combined with Acetaminophen. | Approved, Investigational, Vet Approved |
| Eslicarbazepine acetate | The serum concentration of Acetaminophen can be decreased when it is combined with Eslicarbazepine acetate. | Approved |
| Erythromycin | The metabolism of Acetaminophen can be decreased when combined with Erythromycin. | Approved, Vet Approved |
| Erlotinib | The serum concentration of Erlotinib can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Ergotamine | The serum concentration of Acetaminophen can be increased when it is combined with Ergotamine. | Approved |
| Ergonovine | The serum concentration of Acetaminophen can be increased when it is combined with Ergonovine. | Approved |
| Epinastine | The serum concentration of Epinastine can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Enzalutamide | The serum concentration of Acetaminophen can be decreased when it is combined with Enzalutamide. | Approved |
| Enalapril | The serum concentration of Acetaminophen can be increased when it is combined with Enalapril. | Approved, Vet Approved |
| Eliglustat | The metabolism of Acetaminophen can be decreased when combined with Eliglustat. | Approved |
| Eletriptan | The serum concentration of Eletriptan can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Elbasvir | The serum concentration of Acetaminophen can be increased when it is combined with Elbasvir. | Approved |
| Efavirenz | The serum concentration of Acetaminophen can be decreased when it is combined with Efavirenz. | Approved, Investigational |
| Edoxaban | The serum concentration of Edoxaban can be increased when it is combined with Acetaminophen. | Approved |
| Duloxetine | The metabolism of Acetaminophen can be decreased when combined with Duloxetine. | Approved |
| Dronedarone | The metabolism of Acetaminophen can be decreased when combined with Dronedarone. | Approved |
| Dronabinol | The serum concentration of Acetaminophen can be increased when it is combined with Dronabinol. | Approved, Illicit |
| Doxycycline | The metabolism of Acetaminophen can be decreased when combined with Doxycycline. | Approved, Investigational, Vet Approved |
| Doxorubicin | The serum concentration of Doxorubicin can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Doxorubicin | The serum concentration of Acetaminophen can be decreased when it is combined with Doxorubicin. | Approved, Investigational |
| Doxepin | The serum concentration of Acetaminophen can be increased when it is combined with Doxepin. | Approved |
| Doxazosin | The serum concentration of Acetaminophen can be increased when it is combined with Doxazosin. | Approved |
| Domperidone | The serum concentration of Domperidone can be increased when it is combined with Acetaminophen. | Approved, Investigational, Vet Approved |
| Docetaxel | The serum concentration of Docetaxel can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Disulfiram | The metabolism of Acetaminophen can be decreased when combined with Disulfiram. | Approved |
| Dipyridamole | The serum concentration of Acetaminophen can be increased when it is combined with Dipyridamole. | Approved |
| Diphenhydramine | The metabolism of Acetaminophen can be decreased when combined with Diphenhydramine. | Approved |
| Diltiazem | The metabolism of Acetaminophen can be decreased when combined with Diltiazem. | Approved |
| Dihydrotestosterone | The serum concentration of Dihydrotestosterone can be increased when it is combined with Acetaminophen. | Illicit |
| Dihydroergotamine | The metabolism of Acetaminophen can be decreased when combined with Dihydroergotamine. | Approved |
| Digoxin | The serum concentration of Acetaminophen can be decreased when it is combined with Digoxin. | Approved |
| Digitoxin | The serum concentration of Digitoxin can be increased when it is combined with Acetaminophen. | Approved |
| Diethylstilbestrol | The serum concentration of Diethylstilbestrol can be increased when it is combined with Acetaminophen. | Approved |
| Dicoumarol | Acetaminophen may increase the anticoagulant activities of Dicoumarol. | Approved |
| Diclofenac | The serum concentration of Acetaminophen can be increased when it is combined with Diclofenac. | Approved, Vet Approved |
| Diazepam | The serum concentration of Diazepam can be increased when it is combined with Acetaminophen. | Approved, Illicit, Vet Approved |
| Dextromethorphan | The serum concentration of Acetaminophen can be increased when it is combined with Dextromethorphan. | Approved |
| Dexamethasone | The serum concentration of Acetaminophen can be decreased when it is combined with Dexamethasone. | Approved, Investigational, Vet Approved |
| Desloratadine | The serum concentration of Acetaminophen can be increased when it is combined with Desloratadine. | Approved, Investigational |
| Desipramine | The serum concentration of Acetaminophen can be increased when it is combined with Desipramine. | Approved |
| Delavirdine | The metabolism of Acetaminophen can be decreased when combined with Delavirdine. | Approved |
| Deferasirox | The serum concentration of Acetaminophen can be decreased when it is combined with Deferasirox. | Approved, Investigational |
| Debrisoquin | The serum concentration of Debrisoquin can be increased when it is combined with Acetaminophen. | Approved |
| Daunorubicin | The serum concentration of Acetaminophen can be decreased when it is combined with Daunorubicin. | Approved |
| Dasatinib | Acetaminophen may increase the hepatotoxic activities of Dasatinib. | Approved, Investigational |
| Darunavir | The serum concentration of Acetaminophen can be increased when it is combined with Darunavir. | Approved |
| Darifenacin | The metabolism of Acetaminophen can be decreased when combined with Darifenacin. | Approved, Investigational |
| Dapsone | The risk or severity of adverse effects can be increased when Dapsone is combined with Acetaminophen. | Approved, Investigational |
| Dapagliflozin | The serum concentration of Dapagliflozin can be increased when it is combined with Acetaminophen. | Approved |
| Dactinomycin | The serum concentration of Acetaminophen can be increased when it is combined with Dactinomycin. | Approved |
| Daclatasvir | The serum concentration of Acetaminophen can be increased when it is combined with Daclatasvir. | Approved |
| Dabrafenib | The serum concentration of Acetaminophen can be decreased when it is combined with Dabrafenib. | Approved |
| Dabigatran etexilate | The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Acetaminophen. | Approved |
| Cyproterone acetate | The serum concentration of Acetaminophen can be decreased when it is combined with Cyproterone acetate. | Approved, Investigational |
| Cyclosporine | The metabolism of Acetaminophen can be decreased when combined with Cyclosporine. | Approved, Investigational, Vet Approved |
| Cyclophosphamide | The serum concentration of Acetaminophen can be increased when it is combined with Cyclophosphamide. | Approved, Investigational |
| Crizotinib | The metabolism of Acetaminophen can be decreased when combined with Crizotinib. | Approved |
| Conjugated Equine Estrogens | The serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Acetaminophen. | Approved |
| Conivaptan | The serum concentration of Acetaminophen can be increased when it is combined with Conivaptan. | Approved, Investigational |
| Colforsin | The serum concentration of Acetaminophen can be increased when it is combined with Colforsin. | Experimental |
| Colchicine | The serum concentration of Colchicine can be increased when it is combined with Acetaminophen. | Approved |
| Cocaine | The metabolism of Acetaminophen can be decreased when combined with Cocaine. | Approved, Illicit |
| Cobimetinib | The serum concentration of Cobimetinib can be increased when it is combined with Acetaminophen. | Approved |
| Cobicistat | The serum concentration of Acetaminophen can be increased when it is combined with Cobicistat. | Approved |
| Clozapine | The serum concentration of Clozapine can be increased when it is combined with Acetaminophen. | Approved |
| Clotrimazole | The metabolism of Acetaminophen can be decreased when combined with Clotrimazole. | Approved, Vet Approved |
| Clopidogrel | The metabolism of Acetaminophen can be decreased when combined with Clopidogrel. | Approved, Nutraceutical |
| Clonidine | The serum concentration of Clonidine can be increased when it is combined with Acetaminophen. | Approved |
| Clomipramine | The serum concentration of Acetaminophen can be increased when it is combined with Clomipramine. | Approved, Vet Approved |
| Clomifene | The serum concentration of Clomifene can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Clofazimine | The serum concentration of Acetaminophen can be increased when it is combined with Clofazimine. | Approved, Investigational |
| Clobazam | The serum concentration of Clobazam can be increased when it is combined with Acetaminophen. | Approved, Illicit |
| Clemastine | The metabolism of Acetaminophen can be decreased when combined with Clemastine. | Approved |
| Clarithromycin | The metabolism of Acetaminophen can be decreased when combined with Clarithromycin. | Approved |
| Citalopram | The serum concentration of Citalopram can be increased when it is combined with Acetaminophen. | Approved |
| Cisplatin | The serum concentration of Cisplatin can be increased when it is combined with Acetaminophen. | Approved |
| Ciprofloxacin | The serum concentration of Acetaminophen can be increased when it is combined with Ciprofloxacin. | Approved, Investigational |
| Cinacalcet | The metabolism of Acetaminophen can be decreased when combined with Cinacalcet. | Approved |
| Cimetidine | The serum concentration of Acetaminophen can be decreased when it is combined with Cimetidine. | Approved |
| Cilazapril | The serum concentration of Acetaminophen can be increased when it is combined with Cilazapril. | Approved |