| Ezetimibe | The serum concentration of Ezetimibe can be increased when it is combined with Acetaminophen. | Approved |
| Everolimus | The serum concentration of Everolimus can be increased when it is combined with Acetaminophen. | Approved |
| Etravirine | The serum concentration of Acetaminophen can be decreased when it is combined with Etravirine. | Approved |
| Etoposide | The serum concentration of Acetaminophen can be increased when it is combined with Etoposide. | Approved |
| Ethyl biscoumacetate | Acetaminophen may increase the anticoagulant activities of Ethyl biscoumacetate. | Withdrawn |
| Ethinyl Estradiol | The serum concentration of Ethinyl Estradiol can be increased when it is combined with Acetaminophen. | Approved |
| Ethanol | Ethanol may increase the hepatotoxic activities of Acetaminophen. | Approved |
| Estrone | The serum concentration of Acetaminophen can be decreased when it is combined with Estrone. | Approved |
| Estriol | The serum concentration of Acetaminophen can be decreased when it is combined with Estriol. | Approved, Vet Approved |
| Estramustine | The serum concentration of Acetaminophen can be increased when it is combined with Estramustine. | Approved |
| Estradiol | The serum concentration of Estradiol can be increased when it is combined with Acetaminophen. | Approved, Investigational, Vet Approved |
| Eslicarbazepine acetate | The serum concentration of Acetaminophen can be decreased when it is combined with Eslicarbazepine acetate. | Approved |
| Erythromycin | The metabolism of Acetaminophen can be decreased when combined with Erythromycin. | Approved, Vet Approved |
| Erlotinib | The serum concentration of Erlotinib can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Ergotamine | The serum concentration of Acetaminophen can be increased when it is combined with Ergotamine. | Approved |
| Ergonovine | The serum concentration of Acetaminophen can be increased when it is combined with Ergonovine. | Approved |
| Epinastine | The serum concentration of Epinastine can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Enzalutamide | The serum concentration of Acetaminophen can be decreased when it is combined with Enzalutamide. | Approved |
| Enalapril | The serum concentration of Acetaminophen can be increased when it is combined with Enalapril. | Approved, Vet Approved |
| Eliglustat | The metabolism of Acetaminophen can be decreased when combined with Eliglustat. | Approved |
| Eletriptan | The serum concentration of Eletriptan can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Elbasvir | The serum concentration of Acetaminophen can be increased when it is combined with Elbasvir. | Approved |
| Efavirenz | The serum concentration of Acetaminophen can be decreased when it is combined with Efavirenz. | Approved, Investigational |
| Edoxaban | The serum concentration of Edoxaban can be increased when it is combined with Acetaminophen. | Approved |
| Duloxetine | The metabolism of Acetaminophen can be decreased when combined with Duloxetine. | Approved |
| Dronedarone | The metabolism of Acetaminophen can be decreased when combined with Dronedarone. | Approved |
| Dronabinol | The serum concentration of Acetaminophen can be increased when it is combined with Dronabinol. | Approved, Illicit |
| Doxycycline | The metabolism of Acetaminophen can be decreased when combined with Doxycycline. | Approved, Investigational, Vet Approved |
| Doxorubicin | The serum concentration of Doxorubicin can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Doxorubicin | The serum concentration of Acetaminophen can be decreased when it is combined with Doxorubicin. | Approved, Investigational |
| Doxepin | The serum concentration of Acetaminophen can be increased when it is combined with Doxepin. | Approved |
| Doxazosin | The serum concentration of Acetaminophen can be increased when it is combined with Doxazosin. | Approved |
| Domperidone | The serum concentration of Domperidone can be increased when it is combined with Acetaminophen. | Approved, Investigational, Vet Approved |
| Docetaxel | The serum concentration of Docetaxel can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Disulfiram | The metabolism of Acetaminophen can be decreased when combined with Disulfiram. | Approved |
| Dipyridamole | The serum concentration of Acetaminophen can be increased when it is combined with Dipyridamole. | Approved |
| Diphenhydramine | The metabolism of Acetaminophen can be decreased when combined with Diphenhydramine. | Approved |
| Diltiazem | The metabolism of Acetaminophen can be decreased when combined with Diltiazem. | Approved |
| Dihydrotestosterone | The serum concentration of Dihydrotestosterone can be increased when it is combined with Acetaminophen. | Illicit |
| Dihydroergotamine | The metabolism of Acetaminophen can be decreased when combined with Dihydroergotamine. | Approved |
| Digoxin | The serum concentration of Acetaminophen can be decreased when it is combined with Digoxin. | Approved |
| Digitoxin | The serum concentration of Digitoxin can be increased when it is combined with Acetaminophen. | Approved |
| Diethylstilbestrol | The serum concentration of Diethylstilbestrol can be increased when it is combined with Acetaminophen. | Approved |
| Dicoumarol | Acetaminophen may increase the anticoagulant activities of Dicoumarol. | Approved |
| Diclofenac | The serum concentration of Acetaminophen can be increased when it is combined with Diclofenac. | Approved, Vet Approved |
| Diazepam | The serum concentration of Diazepam can be increased when it is combined with Acetaminophen. | Approved, Illicit, Vet Approved |
| Dextromethorphan | The serum concentration of Acetaminophen can be increased when it is combined with Dextromethorphan. | Approved |
| Dexamethasone | The serum concentration of Acetaminophen can be decreased when it is combined with Dexamethasone. | Approved, Investigational, Vet Approved |
| Desloratadine | The serum concentration of Acetaminophen can be increased when it is combined with Desloratadine. | Approved, Investigational |
| Desipramine | The serum concentration of Acetaminophen can be increased when it is combined with Desipramine. | Approved |
| Delavirdine | The metabolism of Acetaminophen can be decreased when combined with Delavirdine. | Approved |
| Deferasirox | The serum concentration of Acetaminophen can be decreased when it is combined with Deferasirox. | Approved, Investigational |
| Debrisoquin | The serum concentration of Debrisoquin can be increased when it is combined with Acetaminophen. | Approved |
| Daunorubicin | The serum concentration of Acetaminophen can be decreased when it is combined with Daunorubicin. | Approved |
| Dasatinib | Acetaminophen may increase the hepatotoxic activities of Dasatinib. | Approved, Investigational |
| Darunavir | The serum concentration of Acetaminophen can be increased when it is combined with Darunavir. | Approved |
| Darifenacin | The metabolism of Acetaminophen can be decreased when combined with Darifenacin. | Approved, Investigational |
| Dapsone | The risk or severity of adverse effects can be increased when Dapsone is combined with Acetaminophen. | Approved, Investigational |
| Dapagliflozin | The serum concentration of Dapagliflozin can be increased when it is combined with Acetaminophen. | Approved |
| Dactinomycin | The serum concentration of Acetaminophen can be increased when it is combined with Dactinomycin. | Approved |
| Daclatasvir | The serum concentration of Acetaminophen can be increased when it is combined with Daclatasvir. | Approved |
| Dabrafenib | The serum concentration of Acetaminophen can be decreased when it is combined with Dabrafenib. | Approved |
| Dabigatran etexilate | The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Acetaminophen. | Approved |
| Cyproterone acetate | The serum concentration of Acetaminophen can be decreased when it is combined with Cyproterone acetate. | Approved, Investigational |
| Cyclosporine | The metabolism of Acetaminophen can be decreased when combined with Cyclosporine. | Approved, Investigational, Vet Approved |
| Cyclophosphamide | The serum concentration of Acetaminophen can be increased when it is combined with Cyclophosphamide. | Approved, Investigational |
| Crizotinib | The metabolism of Acetaminophen can be decreased when combined with Crizotinib. | Approved |
| Conjugated Equine Estrogens | The serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Acetaminophen. | Approved |
| Conivaptan | The serum concentration of Acetaminophen can be increased when it is combined with Conivaptan. | Approved, Investigational |
| Colforsin | The serum concentration of Acetaminophen can be increased when it is combined with Colforsin. | Experimental |
| Colchicine | The serum concentration of Colchicine can be increased when it is combined with Acetaminophen. | Approved |
| Cocaine | The metabolism of Acetaminophen can be decreased when combined with Cocaine. | Approved, Illicit |
| Cobimetinib | The serum concentration of Cobimetinib can be increased when it is combined with Acetaminophen. | Approved |
| Cobicistat | The serum concentration of Acetaminophen can be increased when it is combined with Cobicistat. | Approved |
| Clozapine | The serum concentration of Clozapine can be increased when it is combined with Acetaminophen. | Approved |
| Clotrimazole | The metabolism of Acetaminophen can be decreased when combined with Clotrimazole. | Approved, Vet Approved |
| Clopidogrel | The metabolism of Acetaminophen can be decreased when combined with Clopidogrel. | Approved, Nutraceutical |
| Clonidine | The serum concentration of Clonidine can be increased when it is combined with Acetaminophen. | Approved |
| Clomipramine | The serum concentration of Acetaminophen can be increased when it is combined with Clomipramine. | Approved, Vet Approved |
| Clomifene | The serum concentration of Clomifene can be increased when it is combined with Acetaminophen. | Approved, Investigational |
| Clofazimine | The serum concentration of Acetaminophen can be increased when it is combined with Clofazimine. | Approved, Investigational |
| Clobazam | The serum concentration of Clobazam can be increased when it is combined with Acetaminophen. | Approved, Illicit |
| Clemastine | The metabolism of Acetaminophen can be decreased when combined with Clemastine. | Approved |
| Clarithromycin | The metabolism of Acetaminophen can be decreased when combined with Clarithromycin. | Approved |
| Citalopram | The serum concentration of Citalopram can be increased when it is combined with Acetaminophen. | Approved |
| Cisplatin | The serum concentration of Cisplatin can be increased when it is combined with Acetaminophen. | Approved |
| Ciprofloxacin | The serum concentration of Acetaminophen can be increased when it is combined with Ciprofloxacin. | Approved, Investigational |
| Cinacalcet | The metabolism of Acetaminophen can be decreased when combined with Cinacalcet. | Approved |
| Cimetidine | The serum concentration of Acetaminophen can be decreased when it is combined with Cimetidine. | Approved |
| Cilazapril | The serum concentration of Acetaminophen can be increased when it is combined with Cilazapril. | Approved |
Ziprasidone The metabolism of Acetaminophen can be decreased when combined with Ziprasidone. Approved Zimelidine The serum concentration of Acetaminophen can be increased when it is…
Reserpine The serum concentration of Acetaminophen can be decreased when it is combined with Reserpine. Approved Regorafenib The serum concentration of Acetaminophen can be increased…
Mitotane The serum concentration of Acetaminophen can be decreased when it is combined with Mitotane. Approved Mitomycin The serum concentration of Acetaminophen can be increased…