Neuropathic pain in diabetic people

Neuropathic pain in diabetic people or diabetic neuropathies is series of nerve disorders caused due to diabetes. People suffering from diabetes after period of time develop damages in nerve all through their body. Some people face no symptoms even with nerve damage whereas others experience problems such as numbness, pain or tingling of legs, feet, arms, hands. Every organ in system like heart, sex organs, and digestive tract can get nerve problems.

Causes of diabetic neuropathies

  1.  The causes vary but the common cause is nerve damage that occurs due to exposure to high levels of blood glucose.
  2. Metabolic factors like prolonged diabetes, abnormal levels of blood fat, low insulin levels, high levels of blood glucose
  3. Neurovascular factors like blood vessel damage and blood vessels carry nutrients and oxygen to our nerves
  4. Autoimmune factors lead to inflammation in our nerves
  5. Mechanical injury to our nerves like carpal tunnel syndrome
  6. Lifestyle factors like alcohol use and smoking
  7. Inherited traits which increase the chances of nerve damage

Symptoms – Diabetic neuropathies

Symptoms solely depend on the nerves that are affected and type of neuropathy and other symptoms are

  • Indigestion, vomiting and nausea
  • Urinating problems
  • Faintness or dizziness due to low blood pressure after sitting or standing up
  • Wasting hand, feet muscles
  • Numbness, pain or tingling in finger, arms, legs feet and toes
  • Constipation or diarrhea

Diabetic neuropathy is basically nerve disorders cause due to the abnormalities that are linked to diabetes like high level of blood glucose. Treatments involve correcting the levels of blood glucose to normal range. Regulating the blood glucose levels can help prevent or starting of future problems. Foot care is considered as essential part of neuropathic pain treatment. People suffering from neuropathic pain having diabetes should take very good care of their feet on a daily basis and check for injuries. If the injuries are left untreated it can lead to infection and foot sores.

Treatment for neuropathic pain in diabetic patients also includes medications for pain relief and other medications depending on the severity of nerve damage. Smoking too increases problems of foot or amputation.

Exercise can also help a lot in showing improvements in neuropathic pain especially in diabetic people.  People having diabetes should consult their doctor before they start with any exercise and once decided; making exercise part of daily routine can be helpful.

Look for exercises with low impact as such exercises are easily tolerated by most diabetic people. Exercises like aerobics, swimming, yoga, are ideal options. These exercises can help improve relaxation skills.

Try to avoid exercises of high impact as such exercises can have adverse impact on neuropathic pain. Exercise can really help in nerve pain and doing it consistently is helpful. Start slowly and then increase the time to half an hour, at least five times in a week. The key is to start slowly and increase the time gradually and be consistent.

In case of neuropathic pain, diabetic people should focus on keeping their sugar levels in control and follow the diet recommended by their doctor.

Herbal Supplements can give you relief from Neuropathic pain

Neuropathic pain is really difficult to manage. In some cases where the pain occurs due to herniated disc can be easily resolved and also the pain can go off. But, in patients having chronic medical conditions like diabetes, prolonged pain due to an injury, even conventional type of pain management techniques aren’t successful.

Dysfunction of nerve cause neuropathic pain and nerves can get damaged due to a disease or an injury and sometimes the reason for the dysfunction remains unknown. People who suffer with neuropathic pain often experience severe, sharp pain that passes through the pathway of affected nerve. The pain can be followed by numbness, weakness, tingling or burning.

Conventional methods used for pain management focus on pharmaceuticals use and medications available for pain management do not work well for relieving neuropathic pain and also include risk like overdose, addiction and organ damage.

Herbal remedies that work well for neuropathic pain like Corydalis is a plant that yields flowers and is used since ages to treat depression, high blood pressure, menstrual cramps, abdominal pain, spastic intestines and other health problems.  The tuber part and roots of the plant are used. Corydalis can be used for people suffering from neuropathic pain and recent research has shown that a compound known as DHCB is quite effective in getting some relief in case of neuropathic pain.

To avoid side effects more and more people are opting for herbal supplements or remedies to treat naturopathic pain. Some herbs that are effective for relieving naturopathic pain are

Cayenne

It is also called as red pepper and is a spice which is used due to its medicinal properties. Capsaicin is a chemical constituent that gives hotness to the pepper. Capsaicin is basically a pain reliever which is being used since decades to promote circulation, improve digestive problems and encourage appetite. As per the research the medicinal use of cayenne is implemented for reduction of pain related to surgery, arthritis, peripheral neuropathy and nerve neuropathy. Capsaicin is also added to oils, creams and gels for applying on affected areas to get relief from pain.

Magnesium

Magnesium is very important mineral that the body uses for formation of fatty acid, protein, clotting blood, creation of new cells, supporting nerve and muscle function and generating energy in our body. The foods containing magnesium are sea food, dark green vegetables, whole grains, legumes, nuts and they are easily available in food stores.

Chiropractic massage

 People suffering from different types of neuropathic pain get benefited from chiropractic massage taken regularly. Massage loosens the tight muscles and aids circulation and nerve connection and also relaxes your body. You can approach a chiropractic professional and start with regular massage sessions to get relieve from neuropathic pain.

There are many herbal remedies and supplements available for treating neuropathic pain, but you need to find out the right one that suits you. As every person and health differs so the treatment one person is taking might not be suitable for the other.

Knowing About Peripheral Neuropathy

Nerve pain related to foot is a common problem and may cause tingling, numbness, burning sensation or weakness can affect your leg. Nerve pain in your foot occurs as a result of damage caused to the nerve that passes through path from your spine to your foot. This causes due to injury, medical condition or side effect of medication you are taking.

Damage caused to the nerve disables the ability to transmit messages thus causing nerve pain in your foot and it is known as neuropathic pain or neuropathy. Nerve pain in foot causes because of two reasons that is either due to peripheral neuropathy which occurs as a result of damage to the nerve in lower leg or foot it. The other reason for nerve pain in foot is due to problems that occur in lower spine. This results in leg, buttock, back nerve pain including pain in foot and weakness.

Foot Neuropathy Due to Spinal Problems

Nerve pain in the foot normally occurs due to problem in your back rather than in your foot.

Peripheral Neuropathy

When the problem occurs with the function of nerves that regulates the messages from spinal to brain and vice versa.  It causes problems in hands and feet. Peripheral neuropathy can develop

  1. Suddenly: can cause because of a traumatic incident.
  2. Develop gradually: tends to progress over the period of time and becomes chronic, which results in slow improvement.

If the damage occurs to one nerve it is termed as mononeuropathy and if it damages more than one nerve it is known as polyneuropathy.

The damage caused due to peripheral neuropathy results in

  • Weakness: difficulty in moving your leg or lifting up the leg.
  • Pain: stabbing, sharp, electric shock which often worsens during night
  • Altered sensation: pins, numbness, tingling or hypersensitivity. It makes you feel like you have worn a sock when actually you are barefoot.
  • Altered co-ordination and balance

Symptoms affect both feet rather than just affecting one and it progresses gradually.

Causes of nerve pain in foot in case of peripheral neuropathy

  • Medical Conditions: Diabetes is the major cause in case of peripheral neuropathy resulting in diabetic nerve foot pain which causes to imbalanced blood sugar levels which disturbs the metabolism of nerves glucose levels. Any diabetic person should take good care of their feet and report their doctor in case they face burning sensation or foot pain.
  • Injury: This may come from an incident or repetitive compression.
  • Infections: for example shingle, leprosy or Lyme disease.
  • Alcoholism: prolonged intake of alcohol can affect the peripheral nerves
  • Medications: peripheral neuropathy can also occur as a result of side-effect that causes due to medications like chemotherapy drugs.

Nerve pain in foot can become serious when you face weakness for example foot drop wherein you are not able to lift your foot, which causes you stumble or trip while walking. Also if you face numbness in between your legs you should see a doctor.

Causes and Treatment for Neuropathic pain

Neuropathic pain is a type of pain that occurs due to problems that happen with signals that takes place through nerves. The causes are many. The common neuropathic pain occurs due to pressure, burn and injury etc., traditional painkillers like codeine, paracetamol, anti-inflammatories aren’t of much help. Neuropathic pain gets relieved with the help of anti-epileptic medicines and antidepressants.

Neuropathic pain is caused when a problem occurs with one or more than one nerves. The nerve function gets affected in such a way that it starts sending pain messages to your brain. In other words it is also described as aching, stabbing, shooting and similar to electric shock.

There are different conditions that affect the functioning of nerves. This includes the following

  • Cancer
  • Pain that occurs after chemotherapy
  • Facial pain
  • Uncommon disorders in nerves
  • Pain in phantom limb
  • Diabetic neuropathy
  • Pain followed by shingles
  • Alcoholism

Treatment for Neuropathic pain

  1. If possible treating the main underlying cause
  2. Physical treatments
  3. Psychological treatments
  4. Medicines

Treating the underlying cause helps ease down the pain. For example if you are suffering from diabetic neuropathy, then keeping a check on your diabetes to keep in control helps reduce the neuropathic pain. If you are suffering from cancer and if it can be treated, it also reduces pain.

Medicines for neuropathic pain treatment

Common and traditional painkillers

In most cases common painkillers like paracetamol, ibuprofen isn’t much effective in reducing down the pain.

Tricyclic antidepressant

In tricyclic group the antidepressants are used to treat neuropathic pain. It is not actually used to treat depression. These antidepressants actually work on treating neuropathic pain apart from treating depression.

Duloxetine

This antidepressant according to the research has shown good results in reducing neuropathic pain. Duloxetine is proved to be a good treatment for diabetic neuropathy whereas it hasn’t worked well for other types of neuropathic pain.

Opiate painkillers

These painkillers are stronger for example morphine, codeine and other related drugs. These drugs cannot be used for a long-term as it has some side-effects associated with it.

Physical Treatments

Depending on the cause and site of neuropathic pain, a specialist may advise some physical treatments to reduce pain. This may include acupuncture, physiotherapy, PENS etc.

Physiological treatments

Pain can get worse due to stress, depression or anxiety. The feeling of having pain and it becomes impossible for the individual to decide how to react to pain and face circumstances. In such cases pain management programs, therapy related to cognitive behavioral, counseling and stress management plays an important role in reducing neuropathic pain and helping people deal with pain easily.

Neuropathic pain directly affects an individual’s life as he/she needs proper guidance and medical help to recover from pain. If the pain is chronic, it might take a longer period of time but again with right counseling and pain management programs the ability to deal with pain becomes easily and patient can deal with pain positively without getting into depression.

Gabapentin for chronic neuropathic pain and fibromyalgia

This review is an update of a review published in 2011, itself a major update of previous reviews published in 2005 and 2000, investigating the effects of gabapentin in chronic neuropathic pain (pain due to nerve damage). Antiepileptic drugs are used to manage chronic neuropathic pain and fibromyalgia.

OBJECTIVES:

To assess the analgesic efficacy and adverse effects of gabapentin in chronic neuropathic pain and fibromyalgia.

SEARCH METHODS:

We identified randomised trials of gabapentin for chronic neuropathic pain or fibromyalgia by searching the databases MEDLINE (1966 to March 2014), EMBASE (1980 to 2014 week 10), and CENTRAL in The Cochrane Library (Issue 3 of 12, 2014). We obtained clinical trial reports and synopses of published and unpublished studies from Internet sources, and searched Clinicaltrials.gov. Searches were run originally in 2011 and the date of the most recent search was 17 March 2014.

SELECTION CRITERIA:

Randomised, double-blind studies reporting the analgesic and adverse effects of gabapentin in neuropathic pain or fibromyalgia with assessment of pain intensity, pain relief, or both, using validated scales. Participants were adults.

DATA COLLECTION AND ANALYSIS:

Three review authors independently extracted efficacy and adverse event data, examined issues of study quality, and assessed risk of bias. We performed analysis using three tiers of evidence. First tier evidence derived from data meeting current best standards and subject to minimal risk of bias (outcome equivalent to substantial pain intensity reduction, intention-to-treat analysis without imputation for dropouts; at least 200 participants in the comparison, 8 to 12 weeks duration, parallel design), second tier from data that failed to meet one or more of these criteria and were considered at some risk of bias but with adequate numbers in the comparison, and third tier from data involving small numbers of participants that were considered very likely to be biased or used outcomes of limited clinical utility, or both.For efficacy, we calculated the number needed to treat to benefit (NNT), concentrating on at least 50% pain intensity reduction, and Initiative on Methods, Measurement and Pain Assessment in Clinical Trials (IMMPACT) definitions of at least moderate and substantial benefit. For harm we calculated number needed to treat for harm (NNH) for adverse effects and withdrawal. Meta-analysis was undertaken using a fixed-effect model. We emphasised differences between conditions now defined as neuropathic pain, and other conditions like masticatory pain, complex regional painsyndrome type 1 (CRPS-1), and fibromyalgia.

MAIN RESULTS:

Seven new studies with 1919 participants were added. Another report (147 participants) provided results for a study already included, but which previously had no usable data. A further report (170 participants) used an experimental formulation of intrathecal gabapentin. Thirty-seven studies (5633 participants) studied oral gabapentin at daily doses of 1200 mg or more in 12 chronic pain conditions; 84% of participants were in studies of postherpetic neuralgia, painful diabetic neuropathy or mixed neuropathic pain. There was no first tier evidence.Second tier evidence for the outcome of at least 50% pain intensity reduction, considered valuable by patients with chronic pain, showed that gabapentin was significantly better than placebo in postherpetic neuralgia (34% gabapentin versus 21% placebo; NNT 8.0, 95% CI 6.0 to 12) and painful diabetic neuropathy (38% versus 21%, NNT 5.9, 95% CI 4.6 to 8.3). There was insufficient information in other pain conditions to reach any reliable conclusion. There was no obvious difference between standard gabapentin formulations and recently-introduced extended-release or gastro-retentive formulations, or between different doses of gabapentin.Adverse events occurred significantly more often with gabapentin. Persons taking gabapentin could expect to have at least one adverse event (62%), withdraw because of an adverse event (11%), suffer dizziness (19%), somnolence (14%), peripheral oedema (7%), and gait disturbance (9%). Serious adverse events (3%) were no more common than with placebo.There were insufficient data for direct comparisons with other active treatments, and only third tier evidence for other painful conditions.

AUTHORS’ CONCLUSIONS:

There was no top tier evidence that was unequivocally unbiased. Second tier evidence, with potentially important residual biases, showed that gabapentin at doses of 1200 mg or more was effective for some people with some painful neuropathic pain conditions. The outcome of at least 50% pain intensity reduction is regarded as a useful outcome of treatment by patients, and the achievement of this degree of pain relief is associated with important beneficial effects on sleep interference, fatigue, and depression, as well as quality of life, function, and work. About 35% achieved this degree of pain relief with gabapentin, compared with 21% for placebo. Over half of those treated with gabapentin will not have worthwhile pain relief. Results might vary between different neuropathic pain conditions, and the amount of evidence for gabapentin in neuropathic pain conditions except postherpetic neuralgia and painful diabetic neuropathy, and in fibromyalgia, is very limited.The levels of efficacy found for gabapentin are consistent with those found for other drug therapies in postherpetic neuralgia and painful diabetic neuropathy.

omega-3 fatty acids can relieve neuropathic pain

Omega-3 fats special are an integral part of cell membranes throughout the body and affect the function of the cell receptors in these membranes. They provide the starting point for making hormones that regulate blood clotting, contraction and relaxation of artery walls, and inflammation. They also bind to receptors in cells that regulate genetic function.

proomega

Likely due to these effects, omega-3 fats have been shown to help prevent heart disease and stroke, may help control lupus, eczema, and rheumatoid arthritis, and may play protective roles in cancer and other conditions.

Ko GD has made an experiment on “Omega-3 fatty acids for neuropathic pain: case series.”

OBJECTIVE:

The aim of this case series study was to investigate and report on patients with neuropathic pain who responded to treatment with omega-3 fatty acids.

METHODS:

Methods: Five patients with different underlying diagnoses including cervical radiculopathy, thoracic outlet syndrome, fibromyalgia, carpal tunnel syndrome, burn injury were treated with high oral doses of omega 3 fish oil (varying from 2400-7200 mg/day of EPA-DHA). Outcome measures were obtained pretreatment and posttreatment. These included validated surveys (short-form McGill Pain questionnaire, DN4 neuropathic pain scale, Pain Detect Questionnaire), objective clinical tools (Jamar grip strength, Lafayette dynamometry, tender point algometry) and EMG Nerve Conduction studies.

RESULTS:

These patients had clinically significant pain reduction, improved function as documented with both subjective and objective outcome measures up to as much as 19 months after treatment initiation. No serious adverse effects were reported.

CONCLUSIONS:

This first-ever reported case series suggests that omega-3 fatty acids may be of benefit in the management of patients with neuropathic pain. Further investigations with randomized controlled trials in a more specific neuropathic pain population would be warranted.

Tooth Pain

Tooth pain or toothache can be usually regarded as ache around exact tooth, jaws or teeth. Tooth ache can range from gentle sensitivity or uneasiness to being unbearably painful. The real ache we feel because of irritation of the nerves which are linked with the teeth/tooth. Here in this article we will explain you the causes and also treatment of tooth pain.

Causes of Tooth Pain:

The most of the tooth pain mainly caused due the dental/oral causes. There are other various causes of tooth pain such as tooth cavity, gum diseases, dental decay, cracked tooth, fracture of the tooth, spasms of the muscles, irritation of the pulp, impacted teeth, tooth infection, faulty diet, swelling of the pulp, ulceration of the gums and excess consumption of soft drinks and many more.

Signs of Tooth Pain:

There are symptoms of tooth pain such as swelling of jaw and around a tooth, ache while chewing, throbbing pain in the tooth, discharge or bleeding around the gums or tooth, hot cold sensitivity and trauma or injury to gums/teeth.

Home remedies for Tooth Pain:

There is not an accurate time for tooth ache to happen. You cannot call your dentist at 2 am at night. Thus, you can use the net searching for home remedies. Though, these should not be alternated for a visit to your doctor for exact reason of pain. Given below are some of the effective home remedies for tooth pain.

Sensodyne therapy is very beneficial for tooth cavities. You have to rinse the mouth with lukewarm water and put max sensodyne toothpaste on the cavity. This will give relief from tooth pain after few minutes.

You can also make use of garlic and rock salt for treating tooth pain. Take a clove of garlic and dip in a rock salt and put under the infected tooth. You can also chew a clove of garlic on an empty stomach. This will help you in treating tooth pain.

You can also chew raw onion on regular basis. It is said that eating a raw onion for few minutes on regular basis is very effective to kill all the germs in your mouth.

You can also prepare a mixture of mustard oil and a pinch of salt and give proper massage to the jaws; this will help you in curing tooth pain and also make the jaws and gums strong.

You can also make use of brandy, you have to dip the cotton ball in the brandy and apply on to the infected area. This would help you in treating tooth pain.

Treatment of Tooth Pain:

The treatments for tooth ache vary greatly. They cure the actual cause of the tooth ache for example: if you are suffering tooth decay, you will have to experience a filling process. If you have impacted Wisdom tooth, then you have to require the extracted and if the tooth decay has attained your pulp, then you need a RCT process. Your doctor will find out the best treatment for you after investigative you.

Trigeminal Neuralgia ? The Suicide Disease

Trigeminal Neuralgia is a sever neuropathic disorder of the facial nerve. It is characterized by serious bouts of pain in the facial region. This pain generally originates from the Trigeminal nerve in the face. Patients affected by this disease generally feel the pain in the eyes, ear, nose, forehead , cheeks, jaw and side of the face. In some cases the pain may be felt in the left index finger also. The duration of the attack may last from a few seconds to several minutes or hours. Researches reveal that people above 50 years get affected and the percentage is more in females than in males.

 

Patients who have been suffering from Trigeminal Neuralgia identify a specific ‘trigger area’ in their face. This area is so sensitive that mere touching or even air currents may initiate the attacks. Common activities like eating, talking and even brushing the teeth can initiate a severe attack. Patients have described the pain to be stabbing, shocking, burning, pressing, crushing, exploding and even shooting. In extreme cases, one, two or all three branches of the trigeminal nerve may be affected.

 

There has been much debate about the causes of Trigeminal Neuralgia. According to new age researches the cause is an ‘enlarged blood vessel’ which in turn compresses or rubs the Trigeminal nerve in the region where it meets the pons. Such severe compression causes episodes of pain.

 

Unfortunately in many cases Trigeminal Neuralgia has been wrongly diagnosed as some dental problem. However, to manage the pain and cure the disease it needs early treatment. Surgery is recommended many a times to cure the disease. It is done either to relieve the compression or to damage it in a way so that the brain stops receiving the pain signals during episodes of attack. Surgery, if done with expert hands has a success rate of 90 per cent.

 

Stereotactic radiation therapy is also used as a treatment for this problem. No surgery or incisions are used in this procedure. It uses targeted radiation to bombard the nerve. However, this treatment is generally recommended for patients who are not fit for surgery.

 

Antivasculants are usually prescribed by the doctors as medication for Trigeminal Neuralgia. Carbamazepine if the first choice and is used as the first line of drug. Others include phenytoin, gabapentin, lamotrigine, baclofen, and oxcarbazepine.

 

Young patients suffering from Trigeminal Neuralgia syndrome may sometimes sink into depression. It is therefore very important to reassure them that treatment for this chronic pain disease exists.

 

For more information about trigeminal neuralgia causes and trigeminal neuralgia treatment visit our website.

Carpal Tunnel Exercises Before And After Surgery

Carpal tunnel syndrome is neuropathic condition stemming from the compression of the median nerve in the carpal tunnel. It’s common manifestations are pain, paresthesia and numbness on the hands and wrists. According to the National Center for Biotechnology Information, one of the most common causes of this illness is constant typing. However , recent studies have also confirmed the contribution of genetics in its development. Palliative treatment for CTS includes the application of night splints as well as corticosteroid injections. Curative treatment, meanwhile, involves surgery. And preventive measures encompassed regular carpal tunnel exercises.

When you begin to feel a tingling, stinging sensation on your wrists after typing, consider resting them for a while. The duration will mostly be dependent on how much pain is felt. While resting, you could ice your wrists for 10 to 15 minutes, once or twice an hour, to decrease the throbbing. To add, you could also take NSAIDs like ibuprofen or naproxen sodium to reduce the swelling and relieve the pain. During the five minute rest intervals, you could additionally perform this carpal tunnel exercise routine to aid in relaxing the wrist muscles.

First, extend and stretch both wrists and fingers with palms facing forward. Hold them for a count of 5.

Then relax fingers and straighten both wrists.

With arms stretch out, make a tight fist with both hands.

Afterwards, bend your wrists downward with the fist still intact. Keep it this way for 5 counts.

And then relax both hands again and keep both wrists straight for five seconds.

Repeat the previous steps ten times and then to culminate the exercise, shake your hands loosely for 10 to fifteen counts.

And at night, it would be best if you use a wrist splint to keep your wrist in neutral position. This will take the pressure off your median nerve and keep you from aggravating the condition. Now, if you have decided to correct the ailment with surgery, it imperative that you execute these carpal tunnel surgery exercises to hasten your recovery.

Extend and bend your fingers slowly with your arms stretched out.

Then make a fist and hold it for 5 counts.

Afterwards, relax your fingers and begin connecting your thumb to your pinky.

Apply pressure on both finger pads for 3 seconds and then relax.

Repeat 10 times during a routine and keep at it two to three times a day, until you can make it an hourly regimen.

For advanced carpal tunnel surgery exercises, you can perform the ulnar glide stretch out your arms to the side with your hands in a stop position. Afterwards, bend your elbows and have your hands reach out to your ears. As you get closer, bend your wrists further so you have them pointing towards your shoulders. After 5 counts, relax, and then repeat the whole thing 10 to 12 times.

You can have someone help you initially with the steps and then move on to doing them independently when you are feeling better. So long as you get to do them as how they are prescribed as frequently as they are urged, you are bound to recover from CTS in no time

Dealing with the Pain in the Nervous System

Any damage or disorder in the nervous systems normally leads to neuropathic pain. Neuropathic pain is a very intricate and never-ending pain acquired as a result of injured or dysfunction of tissue in the nervous system. This is often the case when the nerve fibers are injured, damaged or are not performing as it should.

Neuropathy can result from dysfunctions of the peripheral nervous system or the central nervous system. With damage to the peripheral nervous system, all the nerves branching from the spinal cord to all parts of the body might be affected. Patients with peripheral neuropathic pains can suffer from muscle pains, tingling and numbness, shooting and burning pains, muscle wasting, paralysis, and gland or organ dysfunction.

Certain pains, like central neuropathic pains are often seen as a result of multiple sclerosis, spinal cord injury and other types of injury to the brain like partial paralysis and stroke.

Individuals with diabetes, fibromyalgia, herpes-zoster infection, multiple sclerosis, cancer, and HIV-related disease can suffer from neuropathic pains.

Neuropathy pain relief and treatments:

Antidepressants: These are used to limit the pain signals from the nerve endings to the brain resulting in the relief of neuropathic pain. However , use of antidepressant is not recommended for depressed patients because it may trigger the wrong signals in the brain and alleviate depression instead of the pain.

Anticonvulsants chemical properties: Anticonvulsant plants like hypericum perforatum and coriandrum sativum can block specific neurons on the brain, thus lessening or relieving pain caused by peripheral and central neuropathy.

Opioids: This is becoming more renowned as part of treatment for neuropathic pains. Although not first in line in neuropathic pain treatment, opioids are still considered the most consistently effective relief for this condition. It must be noted that opioids are only appropriate for use in some individuals and close supervision is always recommended.

Anti-inflammatory painkillers: These are commonly used to relieve neuropathic pain. Severe cases may require stronger dosage or painkillers like morphine.

Topical ointments: These can serve as agents mainly used to desensitize the skin nerves and reduce skin sensibility. However , benefits and effects appear to be modest.

Dietary supplements: Dietary supplements that can give relief are benfotiamine and alpha lipoic acid, not only for neuropathic pain but for diabetics also. However , non-diabetic individuals may not reap the same benefits from these dietary supplements.

Spinal cord stimulators: By placing electrodes next to the spine, this will help to treat spinal cord injury from the outside.

Neuropathic pain relief does not only come from pharmacological treatments, but from lifestyle changes like avoiding alcohol; getting cognitive remedial exercise like yoga, massages, chiropractic care, meditation and other types of exercises. Acupuncture is also sought by some neuropathic pain sufferers, which can produce variable results. Long-term solutions without significant complications are still being improved and undergoing clinical trials.

Aarkstore Enterprise – Neuropathic Pain – Pipeline Assessment and Market Forecasts to 2016

Aarkstore announce a new report “Neuropathic Pain – Pipeline Assessment and Market Forecasts to 2016” through its vast collection of market research report.

Summary

The industry analysis specialist’s new report, “Neuropathic Pain – Pipeline Assessment and Market Forecasts to 2016”, is an essential source of information and analysis on the global neuropathic pain market. The report identifies the key trends shaping and driving the global neuropathic pain market. The report also provides insight into the prevalent competitive landscape and the emerging players expected to bring significant shifts in the positioning of the existing market leaders. Most importantly, the report provides valuable insights into the pipeline products within the global neuropathic pain sector.

This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalData’s team of industry experts.

GlobalData estimated the global neuropathic pain market to be valued at $ 4. 8 billion in 2008. It is expected to grow at a Compound Annual Growth Rate (CAGR) of approximately 4. 3% from $ 4. 8 billion in 2008 to $ 6. 5 billion in 2015. This growth will be supported by the increase in the aging population, increased treatment seeking behavior and increased uptake of the current products. The diagnosis rate remains as one of the barriers for the growth of the market. The available treatment options are moderately successful in meeting the market demand. There is still a need for better therapy and there exists unmet needs. There exists a market potential for any new entrant that will cater for these unmet needs. There is enormous opportunity for any drug that could match or better the efficacy provided by the current players with increased safety.

Scope

The scope of the report includes:
– Annualized global neuropathic pain market revenues data from 2001 to 2009, forecast forward for eight years to 2016.
– Pipeline analysis data providing a split across different phases, mechanism of action being developed and emerging trends. Key classes of mechanism of action include opioid receptor agonists, cannabinoid receptor modulators, NMDA antagonists, protein kinase inhibitors, ion channel targetters, serotonin norepinephrine reuptake inhibitors, adenosine agonists, cytokine modulators, AMPA antagonists, nicotinic receptor agonists, TRPV1 receptor agonists, selective subtype sodium channel antagonists and iNOS/nNOS dual inhibitors.
– Analysis of the current and future market competition in the global neuropathic pain market. Key future market players covered are NeurogesX, Cephalon Inc., UCB S. A., Newron Pharmaceuticals, EpiCept Corporation, GW Pharmaceuticals, Johnson & Johnson, Avanir pharmaceuticals, GlaxoSmithKline plc and AstraZeneca.
– Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide a qualitative analysis of its implications.
– Key topics covered include strategic competitor assessment, market characterization, unmet needs and the implications for future market associated with neuropathic pain.

Reasons to buy

The report will enhance your decision making capability in a more rapid and time sensitive manner. It will allow you to:
– Develop and design your in-licensing and out-licensing strategies through a review of the pipeline products and technologies and by identifying companies with the most robust pipeline.
– Develop business strategies by understanding the trends shaping and driving the global neuropathic pain market.
– Drive revenues by understanding key trends, innovative products and technologies, market segments and companies likely to impact the global neuropathic pain market in future.
– Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.
– Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain the competitive advantage.
– Organize your sales and marketing efforts by identifying the market categories and segments that present the maximum opportunity for consolidations, investments and strategic partnerships.
– What’s the next big thing in the global neuropathic pain market landscape? Identify, understand and capitalize.

For more information, please visit:
http://www.aarkstore.com/reports/Neuropathic-Pain-Pipeline-Assessment-and-Market-Forecasts-to-2016-65412.html
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Many People Suffer from Neuropathic Pain

People have neuropathic pain for many reasons. It can be caused by a variety of different illnesses, injuries and accidents, aging and other reasons. It can dramatically impact the quality of a person’s life. Many seek a variety of different treatments to get relief.

Spinal cord injuries are one of the leading causes of this problem. Fibromyalgia, stroke, multiple sclerosis, and other medical conditions can all contribute to this. Cancer, malignancies, chemotherapy are other related conditions. Toxins or nutritional deficiencies cause some of the problems. Diabetic neuropathy is also included because it has similar symptoms.

People who have these conditions may have many different manifestations of pain. They may feel neuropathic pain symptoms that include stabbing, burning, tingling, numbness, itching, pinching, spasms, tremors or feeling like one has had an electric shock. Many of these creep up on people very slowly. It will start out as something that seems fairly insignificant only to become unbearable later. Many people ignore the warning signals until it is causing constant pain.

In some cases, such as that of people who have diabetes, it is possible for other problems to occur as a result of the nerve problems. With this problem, people tend to have numbness in their feet. This can lead to them cutting themselves, getting blisters or other injuries that they may not notice. Because they tend to heal slower than other people, they have a much higher risk of having the injury become infected. This can cause considerable problems and without appropriate medical treatment, they can risk amputation.

People who are seeking neuropathic pain treatment may look in many directions. Most will try to follow any recommendations that their physician gives them. They may try things like antidepressants, opioids, topical medications or other methods depending on what the cause of the problem is. Some will obtain some measure of relief but others will not.

Those who cannot stop the progression or get relief from it may face additional obstacles. They may have trouble with their balance or walking. Ordinary things like carrying a bag of groceries can become difficult or impossible. They may not have the physical strength or dexterity to turn a doorknob or to open a jar. Sleep can be harder to get.

For people who have tried other methods, trying to approach the problem by providing nutritional support may help. Some people feel that good nutrition, rest and things like supplements that contain B vitamins and other minerals may be of use. Neuropathic pain may or may not show an improvement but it may be worth a try for many people.

What is Neuropathic pain ?

Neuropathic pain is the result of an injury or problem with the nerves themselves. The pain is often triggered by an injury or an operation. Any event that can cause an injury to your body has the potential to damage the nerves at the same time.

For example, if a muscle is crushed, then the nerves within the muscle may also be crushed. Nerves can also be damaged or squeezed by tumours and scar tissue, or irritated by an infection.

Neuropathic pain often feels like burning, stabbing, or an electric shock. Strong pain from a light touch is also common. Neuropathic pain may last for months or years – long after the injury appears to have healed. Such pain means the problem is with the nervous system itself.

Examples: Failed Back Surgery Syndrome, Neuralgia, reflex sympathetic dystrophy (nerve damage), certain cancer pain, phantom limb pain, a trapped nerve, and peripheral neuropathy (widespread nerve damage).

There are many causes of peripheral neuropathy, diabetes being the most common. But it can also be caused by chronic alcohol abuse, exposure to toxins (unhealthy chemicals), lack of certain vitamins and a large variety of other problems. The cause is often never known.