Probable and suspected Interactions of Aspirin

Aspirin is linked to several probable and suspected interactions that influence the activity of other drugs. Listed below are some common suspected interactions.

Aspirin can decrease the effects of medications (used for regulating blood pressure) by reducing the levels of blood pressure. This may happen because prostaglandins play a major role in regulating blood pressure.

Aspirin with Methotrexate

When Aspirin is used with aminoglycoside antibiotics or methotrexate the blood levels of aminoglycoside or methotrexate can increase, may be due to their elimination process from the body gets reduced. This leads to many side effects.

Individuals using anticoagulants or oral blood thinners like warfarin should not take aspirin as aspirin also aids blood thinning and can result in severe bleeding.

Some other products that can interact with aspirin are

  • Acetazolamide
  • Blood thinners
  • Mifepristone
  • Cortoicosteroids like valproic acid and other herbal medications like gingko biloba.

Before using Aspirin, speak to your doctor if you had recently taken vaccines like flu vaccine, varicella vaccine etc.,

Check all non prescription and prescription medicine labels properly because many medications comprise of fever reducers, pain relievers called as NSAIDs  like ibuprofen, naproxen etc., to avoid overdose of Aspirin read the labels very carefully before you take other medicines for cold, pain  and make sure these medicines do not contain aspirin.

Using NSAIDs can decrease the aspirin’s potential to prevent heart stroke or heart attack. If you are using Aspirin in low doses for preventing heart stroke or attack, discuss with your pharmacist or doctor for more information and to know about other alternative treatments for fever and pain.

Interactions of Aspirin with Anticoagulants/ Mifepristone

The interactions can be severe. These medicines can interact to yield harmful effects and that’s why should not be used together. Consult your physician for details.

You anticoagulant reduces the blood clot formation ability of your body. This may result in more bleeding and excessive bleeding can be fatal too.

Let your physician know that you are using anticoagulant before you start taking mifepristone. If you have already consumed mifepristone and are also using an anticoagulant, contact your physician immediately. You physician can help treat the problem as he knows the possible risks associated with the drug interaction.

Interactions of Aspirin with Ketorolac(Injectable)

The two medications should not be taken together as this can result in severe effects. The effects of either of the drugs can increase if taken together.  The side effects associated with the other drugs or aspirin can increase and result in stomach pain or stomach upset, bloody stools, drowsiness or dizziness. In some situations even the function of the kidney is affected.

You need to contact your health provider immediately as he can change or adjust your doses accordingly.  Also do not stop, start or change the dosage of medicines you are taking before informing your doctor.
As you do not know the after effects of each drug, it is always better to be safe and consult the physician in advance. You might not know as these effects can be life threatening too.

Facts to know about Aspirin during Pregnancy and Breastfeeding

Aspirin is not recommended during pregnancy as it can have adverse effect on fetus. However, low doses of aspirin have been used safely for preventing pregnancy complications.

FDA has also warned for not using aspirin during pregnancy, especially during the last trimester of pregnancy unless the physicians recommend the use of aspirin as it can cause problems in your unborn child or lead to complications during delivery.

A group of scientists have determined that a developmental toxicant is basically a substance that can harm unborn child. Drugs can lead to dangers to fetus or embryo throughout pregnancy, but the prime concern is during the first three months of pregnancy as vital organs and other systems are in developing phase and during last three months , when there are chances of excessive bleeding that may occur during labor.

As per studies conducted in England, 10-45% of women in first three months of their pregnancy are not aware of their present condition and use the well known OTP medication, aspirin. Aspirin and other medications comprising of salicylate are not safe to be used throughout pregnancy, especially during the last trimester of pregnancy ,except your doctor’s advice.

Since aspirin obstructs the prostaglandin levels, using it in third trimester of your pregnancy can result in premature rerouting of your baby’s blood in uterus and shutting down the ductus arteriousus.

Do not use aspirin when your delivery time is nearing as it can increase the risk of heavy bleeding. Some studies also say that use of aspirin can reduce the fertility as well. If you are using aspirin regularly as part of your treatment and you get pregnant, you should let your doctor know immediately to avoid unwanted effects.

Use of aspirin during first and second trimester of pregnancy has often noticed higher rates of unexpected miscarriages.

Well, in some cases low doses of aspirin are recommended during pregnancy, but after analyzing the possible risks and benefits by a physician only when other alternative and safe treatments aren’t available.

Aspirin and Breastfeeding

Aspirin is believed to be passed through breast milk to the baby and the baby gets 4 to 8 per cent of aspirin dose that mother takes.

Regular exposure of small doses of this medication can be harmful to your baby as aspirin starts building in their body.  Thus the use of aspirin in not recommended in nursing mothers as it there are chances that Reye ’s syndrome can develop in their babies.

Reye ’s syndrome is a medical condition that effects liver and brain and is observed more in children who are on medication for treating viral illness.

To reduce the risks of aspirin, you can check with your doctor if you can take other safe alternative treatments during pregnancy. There are many other alternative treatments available that can help you avoid using aspirin. If your doctor suggests you any other alternative treatment which is safe for you during pregnancy, go for it as it won’t have any side effects and you have a safe pregnancy period and normal delivery.

Dosage instructions that can help you take the right dose- Aspirin

You need to know about the right dosage when taking Aspirin. Knowing about the right dosage can help you know your medicine better.


Aspirin should be consumed with food. Dosage varies between

50 mg – 6000mg on a daily basis depending on the dose prescribed

Normal doses for pain (mild to moderate) – 350mg or 650 mg after every 4 hours

Or 500 mg after every six hours

Rheumatoid Arthritis- Dose

500 mg to be taken after every 4 to 6 hours

650mg after every 4 hours

1000mg – after every 4 to 6 hours

1950mg two times daily

75, 81,162, or 325 mg on a daily basis to prevent heart attack

In case you experience symptoms related to heart attack Aspirin (non-enteric coated) 160- 325mg can be chewed immediately.

For preventing another heart stroke 75-100mg on a daily basis is recommended.

It is recommended that you discard the medicine carefully. Do not flush them in toilet or throw them in drain. You can get in touch with your local waste organizations or pharmacist to know about the right way to dispose the medicine.

What if you missed a dose?

Since Aspirin is meant to be used when needed, you do not need to be on a dosing schedule. If you have maintained a schedule and miss a dose, you can take the missed dose as and when you remember. You can also skip the dose you missed if it is quite late and you need to take medication as per your next schedule. Do not take extra medicine to adjust the missed dose.

What if you overdose?

If you overdose and notice the symptoms of overdose call poison help or emergency medical help. The symptoms of overdose can be hearing loss (temporary), coma or seizure.


If you are using Aspirin for self treatment, you need to follow the directions given on the label.  If you are not sure about the instruction given on the package, speak to your pharmacist or doctor.

You can take this medicine orally with a glass of water. Avoid lying down for minimum 10 minutes after taking this medication. The duration of treatment and dosage entirely depends on your medical condition and how you respond to the treatment.

Do not use this medication for self treatment for pain for more than 10 days. Also avoid using this drug for self treatment of a fever that continues for more than 3 days. You need to consult your doctor in such cases.

If any of the symptoms get worse, seek medical help immediately. Some of the symptoms of overdose are

Mood changes

Pain in throat

Pain in stomach

Rapid breathing



There are different aspirin products available like some come with special coating whereas others are long-acting. Check with your pharmacist or doctor, which one suits you the best.

You need to be aware about how to use the medicine and avoid overdose. Even using the medicine for self treatment has some limitations and you should follow them.

Aspirin – Common to Severe side effects

Side effects are a serious concern for people using Aspirin, and these side effects range from mild to quite severe problems. The mild ones are very common and include upset stomach, heartburn and nausea. Less common or severe side effects include bloody stools, persistent vomiting, drowsiness and stomach pain(severe)

Aspirin – common side effects

Many people who take aspirin do not experience any kind of side effects related to the drug, however, the common side effects observed are

  • Nausea
  • Headache
  • Heartburn
  • Upset stomach

The above listed side effects are not dangerous, but you should consult your physician immediately if these side effects turn severe or continue to exist for more than 2 days.

Most people using this medication noticed very mild side effects and found no reason to stop medication.

Aspirin- Severe side effects

Serious or severe side effects related to aspirin are rare but need attention when noticed. As with all other NSAIDs drugs, the more severe side effects are related to gastrointestinal and occur without any warning. These are

Serious allergic reactions distinguished by breathing problems, hives and facial swelling.

Severe stomach ulcers and stomach pain

Ringing ears

Black or bloody stools

Severe diarrhea

If you are experiencing any such serious side effects, ask for medical help immediately, especially in case of  a severe allergic reaction.

Aspirin – Side effects in children under 12

Although aspirin is believed to be safe for children under age of 12 for treating pain and swelling related to injury, there are some limitations about its usage for pain or fever related to flu symptoms or fever because of high risk of Reye’s syndrome. This is a serious disorder which is activated by using Aspirin to treat chicken pox, common cold and flu.

Aspirin – Side effects in Elderly people

Aspirin is known for increasing the risk of bleeding due to its properties which include blood thinning . In elderly people, this side effect of the drug is aggravated due to age-related thinning of intestinal walls and stomach walls. Some clinical reports say that the side effects of are greater than the associated benefits of Aspirin to old patients. Older citizens above 65 years of age, using Aspirin, should be constantly monitored by their doctors to understand the severe gastrointestinal problems that can occur unexpectedly.

Nervous system

The side effects Aspirin related to central nervous system are

  • Coma
  • Confusion
  • Lethargy
  • Dizziness
  • Headache
  • Agitation
  • Cerebral edema
  • Seizures
  • Cranial hemorrhage
  • Hearing loss
  • Tinnitus


  • Respiratory – side effects include
  • Pulmonary edema
  • Hyperpnea
  • Tachypnea


The oncologic side effect includes  pancreatic cancer.

The side effects are also seen in pregnant and breastfeeding women. They should be extra careful while using Aspirin. They should discuss with their doctor during their pregnancy period or if they are nursing mothers. Aspirin can affect unborn baby and nursing baby too.  Your physician can help you know whether you should take Aspirin or not.

Aspirin an effective NSAID for treating inflammation

Aspirin is a NSAID ( non-steroidal anti-inflammatory drug), which is highly effective in treating inflammation, pain and fever. It is also useful in preventing blood clots. Since it belongs to NSAIDs a group of narcotic drugs, it is helpful treating mild to moderate type of pain. Sometimes it is also used to prevent or treat heart strokes, attacks and chest pain.

Aspirin must be used only under doctor’s supervision for cardiovascular conditions.

Some important information related to Aspirin

You should avoid using Aspirin if you are suffering from a bleeding disorder like hemophilia, or in case of having intestinal or stomach bleeding medical history. Also avoid using Aspirin if you are allergic to any of NSAIDs.

The generic name is Aspirin. The brand names include Bayer Aspirin, Ecotrin and many others.

Avoid giving Aspirin to teenager or child having flu symptoms, fever or chicken pox. It can cause a serious condition known as Reye’s syndrome in children, which can be fatal too.

To ensure if the medicine is safe for you or not, consult your doctor if you have the following ailments

  • Kidney disease
  • Clotting or bleeding disorder
  • Liver disease
  • Stomach ulcers
  • Seasonal allergies or asthma
  • Gout
  • Heart failure or High Blood pressure

Is Aspirin Addictive?

Aspirin is an absolutely non-additive drug. When it comes to withdrawal or tolerance, some people tend to develop a conscious psychological need to tackle imagined or real pain.

How to take Aspirin?

Always store Aspirin away from heat and moisture in a room temperature at room temperature. If you have to undergo surgery, inform your doctor in advance that you are using this medication.

Always take Aspirin as prescribed by the doctor or as directed on the label. Do not take Aspirin is excess amounts or for long term than prescribed.

In case you get upset stomach due to Aspirin consumption, take Aspirin with food. The chewable tablet form of the medication should be chewed before you swallow it.

If you are using orally dispersible or disintegrating tablet, follow the instructions given for right dosing. Try not to take the medicine if you get a strong vinegar odor in the bottle as the medicine may be no longer effective.

Do not consume alcohol when using Aspirin. Consumption of alcohol can increase the risk of stomach bleeding.

Also get in touch with your doctor if you are taking any allergy, cold or pain medication. There are also many drugs that interact with Aspirin, so you should always consult with the doctor and let him know about any other medication you are using.

The Aspirin quite safe as compared to other drugs as it is not an addictive drugs still it has its side effects and you need to be careful before using Aspirin. Your doctor is the right person to guide you and prescribe the right dose. So do not start taking Aspirin without consulting your doctor. You need to understand about your medicine before you actually start using it.

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