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What are possible Side Effects of Medicines for Gout?

The following possible side effects of medicines for gout are listed by the U.S. Food and Drug Administration (FDA) and in reports from research.

colchicine
colchicine

Just because a side effect is possible does not mean you will have it.

Possible Side Effects of Medicines for Gout

Drug Class Medicine Possible Side Effects Warnings
NSAIDs (nonsteroidal anti-inflammatory drugs) Ibuprofen (Advil®), indomethacin (Indocin®), and naproxen (Aleve®, Naprosyn®)
  • NSAIDs can increase the risk of serious stomach problems such as bleeding or ulcers.
  • NSAIDs can increase the chance of having a heart attack or a stroke.
  • People with kidney problems should talk with their health care professional before taking NSAIDs.
Anti-inflammatory medicine Colchicine
  • In people with kidney and liver problems, colchicine can cause a life-threatening interaction when taken with certain other medicines. People with kidney and liver problems should talk with their health care professional before taking colchicine.
  • In rare cases, colchicine can cause muscle damage and blood disorders.
  • Taking more colchicine than prescribed can lead to overdose and death.
Corticosteroids Prednisone and triamcinolone
  • Fluid rentention (body tissues hold extra water)
  • Mood changes
  • Increased appetite
  • Weight gain
  • Insomnia (trouble falling asleep or staying asleep
Corticosteroids can cause high blood pressure, high blood sugar, or both.
Medicines to

lower uric acid

Allopurinol (Zyloprim®)
  • Nausea
  • Diarrhea
  • Skin rash
  • Increased risk of gout attack when first starting to take it
  • If you get a skin rash while taking allopurinol or febuxostat, call your health care professional right away.
  • In very rare cases, allopurinol and febuxostat can cause severe skin reactions that can be life threatening. Symptoms may include red, blistered, or peeling skin; red or sore eyes; fever; and sores in your throat, mouth, or nose.
  • Allopurinol and febuxostat may affect how well your liver works. These medicines can also cause liver damage. Signs of liver problems can include feeling tired and weak, nausea, vomiting, yellowed skin or eyes (jaundice), and dark-colored urine.
Febuxostat (Uloric®)
  • Nausea
  • Skin rash
  • Joint pain (not caused by gout)
  • Increased risk of a gout attack when first starting to take it
  • If you get a skin rash while taking allopurinol or febuxostat, call your health care professional right away.
  • In very rare cases, allopurinol and febuxostat can cause severe skin reactions that can be life threatening. Symptoms may include red, blistered, or peeling skin; red or sore eyes; fever; and sores in your throat, mouth, or nose.
  • Allopurinol and febuxostat may affect how well your liver works. These medicines can also cause liver damage. Signs of liver problems can include feeling tired and weak, nausea, vomiting, yellowed skin or eyes (jaundice), and dark-colored urine.

Posted in Pain Medications

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