Side effects of Doxepin hat you need to monitor carefully

This article will help you know about the side effects of Doxepin that you need to monitor carefully and call medical help in case of emergency.

Anticholinergic Effects
·         Constipation
·         Urinary retention
·         Blurred vision
·         Dry mouth
If the above side effects do not subside with regular therapy or become serious, your doctor may reduce the dosage of Doxepin.
CNS effects
Drowsiness is the most common side effect observed in patients. This effect disappears as the patient starts receiving the therapy. Other CNS side effects that do not occur quite often are
·         Hallucinations
·         Hypertension
·         Cardiovascular effects
·         Hypotension
·         Tachycardia
Allergic effects
·         Edema
·         Skin rash
·         Pruritus
·         Photosensitization
Eosinophillia is seen in a few patients. Occasional reports of depression of bone marrow are exhibited as purpura, leukpenia, thrombocytopenia, and agranulocytosis.
·         Endocrine
·         Raised libido
·         Gynecomastia (in males)
·         Testicular swelling
·         Enlargement of breasts
·         Galactorrhea (in females)
·         Increase or decrease in blood sugar levels
·         Vomiting
·         Nausea
·         Taste disturbances
·         Indigestion
·         Diarrhea
·         Anorexia
Other side effects are
·         Dizziness
·         Weight gain
·         Chills
·         Weakness
·         Fatigue
·         Dizziness
·         Flushing
·         Alopecia
·         Jaundice
·         Angle closure glaucoma
·         Hyperpyrexia
·         Asthma
·         Sweating
·         Tinnitus
·         Headache
·          Mydriasis
Major side effects are
·         Stomach or abdominal pain
·         Bleeding gums
·         Canker sores
·         Chills
·         Chest pain
·         Blood in stools or urine
·         Convulsions
·         Dark urine
·         Decreased urine volume
·         Hoarseness or cough
·         Pale or cool skin
·         Cold sweats
·         Depression
·         Drooling
·         Breathing difficulty
·         Urinating difficulty
·         Dry, flushed skin
·         Fever
·         Irritability
·         Nightmares
·         Noisy breathing
·         Restlessness
·         Shuffling walk
·         Slurred speech
·         Vomiting blood
·         Yellow skin or eyes
·         Trembling, unsteadiness or problems with muscle coordination or control
·         Unusual bruising or bleeding
·         Stupor
·         Swollen glands
Common side effects are
·         Feeling tired, drowsy or dizzy
·         Vomiting, constipation, nausea
·         Blurred vision, dry mouth
·         Decreased interest in sex
·         Breast swelling in females and males
Frequency not known
·         Agitation
·         Insomnia
·         Sweating
·         Anxiety
·         Headache
·         Confusion, parenthesis
·         Sexual dysfunction
·         Skin rash
·         Lethargy, weakness, fatigue or sedation
Symptoms of overdose
·         Disturbed concentration
·         Clumsiness
·         Enlarged pupils
·         Muscle aches
·         Shivering
·         Sleepiness
·         Weight gain
·         Feeble or weak pulse
·         Low body temperature
·         Muscle weakness
·         Excessive unconsciousness
Occurrence not known
·         Heartburn
·         Diarrhea
·         Severe sunburn
·         Inability to have erection or keep erection
·         Loss in sexual drive, desire, ability or performance
·         Increased sexual drive, desire, ability or performance
·         Increased skin sensitivity to sunlight
·         Swollen testicles
·         Unexpected flow of milk from breasts
·         Weight loss
·         Discoloration or redness of skin
·         Gas in stomach
·         Change in taste
·         Hair thinning or hair loss

Proper use of Doxepin can help you get maximum benefits

Proper use of any drug can give you maximum benefits whereas not taking the right dosages can lead to complications. Take Doxepin as directed by your physician and avoid taking it very often or for a prolonged period than recommended by your doctor.

You should read the instructions given on the label and in the medical guide that you get, along with the medicine. In case you have any questions you should ask your doctor.

If you are taking the oral liquid form of Doxepin

  1. Use the calibrated dropper provided with the medicine to measure the dose
  2. Take 4 ounces of water (one-half glass), skimmed or whole milk, grapefruit juice, prune juice, pineapple juice, tomato juice or orange juice to mix each dose. Avoid mixing this medicine with carbonated beverages or grape juice. Prepare the medicine mix just before you use it. Do not prepare it in advance.

To use Doxepin tablet

  1. Avoid taking this medicine at least for 3 hours after your meal. It may not show its effect or make you drowsy and sleepy until next day if you take the medicine with meal or just after the meal.
  2. Take the doxepin tablet half an hour before bedtime, when you are going to sleep.
  3. Avoid taking medicine if you can’t get 7-8 hours of sleep as if you wake up early you may feel drowsy.

Dosing Information

The doxepin dose differs from person to person.  Follow the instruction of your doctor or directions mentioned on the label. The information provided below gives you details of the average doses of doxepin. If you are using a different dose do not change your dose until and unless your doctor asks you to do so.

The amount of doxepin you use depends on the medicine’s strength and also on other factors like number of doses used each day, the time gap between two doses and duration after which you use the medicine solely depends on the specific medical problems for which you are taking doxepin.

Oral dosage- solution or capsules

For anxiety of depression

Adults and children aged 12 years and above

Initial dose: 75mg/day or in split doses throughout the day. You doctor will adjust the dose as required.

However the maximum dose should not exceed 150mg/per day

Oral dosage- tablets

For insomnia

Adults 6 mg/day

Older adults

Initial dose – 3mg once in a day

Your doctor will adjust the dose as required.

Missed Dose

In case you miss a Doxepin dose, take it as soon as it strikes your mind. If it is time for your next dose, skip the dose you missed and follow the normal dosing schedule. Do not take extra dose to make up for the missed dose.

Use a closed container to store the medicine and keep it at room temperature away from direct light, moisture and heat. Keep the medicine away from children. Look for expiry date and do not use the medicine that crosses the expiry date.

Is Doxepin unsafe to use during pregnancy and breastfeeding

Doxepin and Pregnancy

Doxepin can be unsafe to use during pregnancy or breastfeeding. In animal studies the medicine has exhibited harmful effects to the foetus when used in high doses. However, doctors still recommend Doxepin during pregnancy if they feel that the benefits of the medicine are higher than the risks to the foetus in pregnant women.

If you are using Doxepin and you get pregnant, let your doctor know. Using Doxepin hydrochloride during pregnancy is not safe. A few studies reported birth defects in humans.

Animal studies have shown that when Doxepin was given during pregnancy in animals, it enhanced the risk of structural abnormalities, low weight in foetus, and low rates of survival in new born. In a few studies its has been reported that use of Doxepin during pregnancy is linked to some birth defects like cleft palate, heart defects and too many toes and fingers. This is not been confirmed in any other study.

Make sure you consult your doctor before using Doxepin during pregnancy so that your doctor can determine the benefits and risks associated with use of Doxepin in pregnancy based on your current medical condition.

Use of Doxepin during first/second trimester of pregnancy increased the rate of infant mortality.

Doxepin and Breastfeeding

Women who are using Doxepin during breastfeeding should know that the medicine can pass to their babies via breast milk. Some health problems seen in babies whose mothers used Doxepin during breastfeeding are jaundice, breathing problems, drowsiness and vomiting. If you are a nursing mother, let your doctor know so that he can guide you whether you can take this medicine or not.

Looking at the harmful effects of medicine and as the medicine secretes in breast milk, the use of Doxepin is generally not advised. As there are many other alternative medicines available to treat depression or anxiety, your doctor can suggest you trying a different medication. In other case if the symptoms of depression are quite severe; your doctor might suggest you to discontinue breastfeeding.

Talk to your doctor before taking Doxepin as each case is different and depending on your current health condition, you doctor can suggest you a better option. If your doctor prescribes you Doxepin to combat severe symptoms of depression, make sure you monitor your baby closely to check for any unusual symptoms and call the doctor immediately if you notice any unusual symptoms.

You can also choose to stop breastfeeding for a short period while you are on this medication to ensure your child’s better health. In case you can use alternative non narcotic medications to treat depression, go for it as they will not harm your baby’s health and also treat depression safely.

Even doctors recommend all natural medicines, meditation, yoga and other therapies that can help you overcome depression without taking narcotic medicines that can harm your baby.

Speak to your doctor for proper guidance and wise decision. He can examine you and suggest you a better option.

1 2