Effective Amoxapine dosage can vary from one person to another. It is always better to check with your doctor before you start using Amoxapine. The right dosage can give you maximum benefits whereas overdose can lead to many other complications. Let us learn about the Amoxapine right dosage and directions.
Normal effective dose is
200-300mg on a daily basis
Three weeks is a sufficient period of trial, providing dosage reaches 300 mg daily for minimum 2 weeks. If the desired response is not seen at 300mg, the dosage can be increased, based on patient’s tolerance say up to 400mg daily.
Patients who are hospitalized and are unmanageable to antidepressant therapy and do not have history of convulsive seizures can get increased dosage of up to 600mg in split doses. Amoxapine can be prescribed as a single dose of not more than 300 mg to be taken daily ideally at bedtime.
Starting doses for Adults
Normal starting dose is
50 mg twice or thrice a day
Based on tolerance, dosage can be increased to 100mg – twice or thrice a day till end of the first week. An increased dose above 300mg is given only when the dose of 300mg proves to be ineffective during the test period of minimum two weeks. When effective dose is built, the drug can be given as a single dose of not more than 300mg during bedtime.
Generally, low dosages are prescribed for elderly patients. Initial Amoxapine dose recommended is
25mg – twice or thrice a day
If no tolerance is noticed, dosage can be increased at the end of first week to 50mg twice or thrice a day. Although 100-150mg daily dosage is sufficient for a lot of elderly patients, some of them may need higher dosage. Cautious increases up to 300mg on a daily basis are suggested in such cases.
When an effective dose is reached, the Amoxapine single dose of not exceeding 300 mg can be given at bedtime.
Suggested maintenance Amoxapine dosage is the lowest possible dose that can maintain remission. If symptoms come back again, dosage needs to be decreased to the earlier dose until the symptoms are controlled.
Amoxapine Over dosage treatment
Amoxapine over dosage treatment should be supportive and symptomatic, with a special medical care to control or prevent seizures. If patient has lost his consciousness, induced emesis accompanied by gastric lavage with necessary precautions to avoid pulmonary aspiration should be achieved faster. During the process of lavage, activated charcoal can be regulated to reduce absorption and repeated supervision can help in eliminating drug from the patient’s body.
A sufficient airway should be built in patients who are in coma and supported ventilation if required. Seizures can respond to usual anticonvulsant therapy like intravenous phenytoin and diazepam. Convulsions normally appear after 12 hours of drug ingestion.
In case of symptoms of Amoxapine over dose, immediately call medical help so that the patient gets treatment in time. This can help avoid fatal complications.