Learning about Amoxapine dosage and directions

Effective Amoxapine dosage can vary from one person to another. It is always better to check with your doctor before you start using Amoxapine. The right dosage can give you maximum benefits whereas overdose can lead to many other complications. Let us learn about the Amoxapine right dosage and directions.

Normal effective dose is

200-300mg on a daily basis

Three weeks is a sufficient period of trial, providing dosage reaches 300 mg daily for minimum 2 weeks. If the desired response is not seen at 300mg, the dosage can be increased, based on patient’s tolerance say up to 400mg daily.

Patients who are hospitalized and are unmanageable to antidepressant therapy and do not have history of convulsive seizures can get increased dosage of up to 600mg in split doses. Amoxapine can be prescribed as a single dose of not more than 300 mg to be taken daily ideally at bedtime.

Starting doses for Adults

Normal starting dose is

50 mg twice or thrice a day

Based on tolerance, dosage can be increased to 100mg – twice or thrice a day till end of the first week. An increased dose above 300mg is given only when the dose of 300mg proves to be ineffective during the test period of minimum two weeks. When effective dose is built, the drug can be given as a single dose of not more than 300mg during bedtime.

Elderly patients

Generally, low dosages are prescribed for elderly patients. Initial Amoxapine dose recommended is

25mg – twice or thrice a day

If no tolerance is noticed, dosage can be increased at the end of first week to 50mg twice or thrice a day. Although 100-150mg daily dosage is sufficient for a lot of elderly patients, some of them may need higher dosage. Cautious increases up to 300mg on a daily basis are suggested in such cases.

When an effective dose is reached, the Amoxapine single dose of not exceeding 300 mg can be given at bedtime.


Suggested maintenance Amoxapine dosage is the lowest possible dose that can maintain remission. If symptoms come back again, dosage needs to be decreased to the earlier dose until the symptoms are controlled.

Amoxapine Over dosage treatment

Amoxapine over dosage treatment should be supportive and symptomatic, with a special medical care to control or prevent seizures. If patient has lost his consciousness, induced emesis accompanied by gastric lavage with necessary precautions to avoid pulmonary aspiration should be achieved faster. During the process of lavage, activated charcoal can be regulated to reduce absorption and repeated supervision can help in eliminating drug from the patient’s body.

A sufficient airway should be built in patients who are in coma and supported ventilation if required. Seizures can respond to usual anticonvulsant   therapy like intravenous phenytoin and diazepam. Convulsions normally appear after 12 hours of drug ingestion.

In case of symptoms of Amoxapine over dose, immediately call medical help so that the patient gets treatment in time. This can help avoid fatal complications.

Is Amoxapine safe for use in pregnant women and nursing mothers?

Many women during their pregnancy experience different types of pain like pelvic pain, knee pain, back pain etc., which is due to the hormonal changes in their body and weight gain during pregnancy. Apart from pain, many women also face depression during their pregnancy or breastfeeding. In both phases of their lives, it becomes difficult to decide which medications they should consider to eradicate pain or manage depression.  During pregnancy or breastfeeding a woman has to always think about her baby before taking any medication as they are not aware about how the medication is going to work for them or their baby.

While pregnancy is believed to be the period of joy, but this is not the case for every woman.  At least one out of 10 pregnant women suffer from depression. Due to the fluctuation in hormones during pregnancy, many women face depression.

Same thing can happen in case of nursing mother who after the birth of their baby find it difficult to manage depression. In such situations both nursing mothers and pregnant woman often opt for a medication like Amoxapine to manage depression.

Amoxapine and Pregnancy

There are still no sufficient studies available that can justify the use of Amoxapine in pregnancy. Amoxapine should be taken during pregnancy only if has high benefits than risk for you and your baby. Speak to your doctor if you want to use Amoxapine. Use Amoxapine only if your doctor recommends you.  If you are already using Amoxapine and get pregnant, let your doctor know that you are pregnant.

Amoxapine and Breastfeeding

Since it is not easy for nursing mothers to manage depression and care for their babies, they always look for a medication that can control their depression levels without knowing how it is going to affect the lactation or baby’s health.

Amoxapine like any other drugs get transferred into breast milk. Since the effect of Amoxapine on infants is still not known, doctors should take extra caution before prescribing Amoxapine to nursing mothers.  There are possibilities of serious effects to the baby, so speak to you paediatrician before using Amoxapine.

Not adequate research is available on use of this medication in nursing women. It is still not clear how much Amoxapine gets transferred into breast milk and if it is harmful for the baby. It is safer to consult your health care provider as each case is different and based on the medical condition, your doctor can decide whether to take Amoxapine during breastfeeding or not.

It also depends on your current health situation as what is the right dose for you and if you can continue with breastfeeding. You wouldn’t want to harm your baby isn’t? So you can also try alternative medications that can manage depression and would not harm your baby. Speak to your doctor to suggest you safe alternative medications so that you can avoid taking Amoxapine during breastfeeding as Amoxapine comes with a lot of side effects too, which can be troublesome for you while you are taking care of your baby.

Desired effects accompany unwanted side effects too- Amoxapine

Like any other antidepressants, Amoxapine too comes with unwanted side effects. If you are using Amoxapine to get needed effects, then do not forget you should also need to check for the possible and unwanted side effects that accompany the desired effects. This article will help you know about common, major, minor, overdose and other side effects related to Amoxapine.

Commonly reported Amoxapine side effects include drowsiness. Other side effects:  blurred vision

Major Side effects that need immediate medical help are

  • nightmares
  • excitement
  • mental or mood changes
  • trouble sleeping
  • unsteady walk
  • nervousness or fear
  • racing,, pounding, irregular, fast pulse or heartbeat
  • restlessness
  • swelling
  • trembling, unsteadiness or problems like muscle coordination or control
  • shakiness in feet, hand arms and legs


  • bloating
  • stomach or abdominal pain
  • blurred vision
  • discomfort or chest pain
  • bleeding gums
  • tarry, black stools
  • stomach or abdominal pain
  • chills
  • discomfort or chest pain
  • confusion
  • crawling,, itching, burning, tingling or prickling feelings
  • blood in stools or urine
  • constipation
  • convulsions
  • confusion about time, place or identity
  • hoarseness or cough
  • continuing buzzing or ringing or other noise in ears
  • dark urine
  • drooling
  • double vision
  • disturbed concentration
  • breathing problems
  • dribbling
  • extremely high body temperature or fever
  • weak or fast heart beats
  • fever without chills or with chills
  • headache
  • high fever
  • hearing loss
  • increasing sweating
  • welts or hives
  • itching
  • irritability
  • indigestion
  • appetite loss
  • muscle cramps
  • numbness
  • nervousness
  • clammy or pale skin
  • skin redness
  • sweating
  • thirst
  • swollen glands
  • yellow skin or eyes

Overdose symptoms which can be quite severe and need immediate medical attention are

  • drowsiness
  • fatigue
  • increased thirst
  • increased BP
  • complete body jerking
  • weight gain
  • breathing problems
  • swelling of lower legs, face or fingers
  • epileptic seizures which doesn’t stop

Minor Side effects

Some minor side effects do not need medical attention and vanish with time. These side effects disappear as your body gets used to the medication. But if these side effects last for long and become troublesome, speak to your doctor immediately.

More Common

  • dry mouth

Less Common

  • increased flow of milk from breast
  • increased appetite


  • breast enlargement
  • agitation
  • full feeling
  • decreased in intercourse(sexual)
  • depression
  • excess gas or air in intestines or stomach
  • menstrual changes
  • increased skin sensitivity to sunlight
  • increased sexual ability, drive, desire or performance
  • heartburn
  • thinning of hair or hair loss
  • passing gas
  • nasal stuffiness
  • painful ejaculation
  • stupor
  • severe sunburn
  • seizures
  • fast weight gain
  • discoloration or redness of skin

In case you experience side effects that you think are severe and need medical attention, do not ignore them as need immediate medical treatment.

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