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Uses, Interactions and Side effects of Apo- Desipramine

Desipramine helps eliminate depression symptoms and elevating mood. You should consult your doctor before taking this medication and do not pass the medication to others who show the same symptoms like you. It can be risky.


For treating depression especially in adults, the prescribed dose should be taken with food or without food. Gradually the dose is increased until the right dose is determined. It can take several weeks for the medication to show its full effect and the individual using the medication should be patient enough to see the results.

There are various factors that can affect dose of any medication that a person requires, like medical conditions, body weight and other medications. So do not change the dose as prescribed by the doctor without consulting him/her.

Avoid disposing medication in household garbage or wastewater. You can check with your pharmacist to know about the disposal method if you don’t need the medicine or have expired set of medicines.

You should avoid taking this medication if you are

  1. Allergic to Desipramine or any specific ingredient present in this medication
  2. Had suffered from a heart attack recently
  3. Have a heart block or congestive heart failure(acute)
  4. Taken MAO inhibitor 14 days back.

Side effects – Desipramine

Medications cause side effects and it’s an unpleasant response to a particular medication. Side effects basically are permanent, severe or temporary. Some of the side effects listed below aren’t faced by all who take this medication. You can ask for medical help if you experience the following side effects

    • Itchy skin
    • Constipation
    • Rash
    • Blurred vision
    • Abdominal cramps
    • Nausea
    • Drowsiness
    • Sexual dysfunction
    • Excitement
    • Weight gain
    • Vomiting
    • Headache
    • Muscle twitching
    • Sweating
    • Irregular or increased heart rate
    • Irritability
    • Sleeping problems
    • Urinating problems

You also need to seek the help of your doctor if you notice the following side effects

Blurred vision, seizures, eye pain, shuffling walk, slowed movements, fainting, confusion, hair loss, fever or sore throat, swelling of tongue or face, hallucinations, constipation, trembling or shakiness, unexplained sounds experienced in ears, brownish or red spots on your skin, breast enlargement in both women and men, yellow skin or eyes, muscle twitching, losing control over the balance, swollen testicles, sensitivity to light increases, restlessness or nervousness.

Your doctor should know about your medical conditions, if you are pregnant, nursing mother or any other related factors about your health that you think your doctor should know.

Both lowering and increase in levels of blood sugar has been noticed in diabetic people with the use of Desipramine. Diabetic people or people suffering from hypoglycemia should keep a check on the levels of blood sugar when using this medication.

Desipramine also leads to irregular heart rhythms especially when you take in high doses. Thus people suffering from heart disease should use Desipramine carefully. Similarly in case of thyroid disease or seizures you should consult the doctor before using Desipramine.

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