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Knowing about possible Toradol drug interactions

Drug interactions can change how a medication works for you and knowing about these drug interactions can help you identify the side effects caused due to these drug interactions. This article will help you know about some drugs that can interact with Toradol.


When aspirin and Toradol are used together, the protein binding is decreased, though the clearance of this medication (Toradol) doesn’t change. Using these two medications is not recommended because of the harmful effects associated with this combination.


Using the combination of Toradol and Probencid resulted in reduced volume and clearance of distribution of ketorolac and remarkable increase in plasma levels of ketorolac.


According to clinical studies Toradol is capable of reducing the natriuretic effect of thiazides and furosemide in some cases. This combination resulted in obstruction of renal prostaglandin synthesis. During this therapy the patients should be closely monitored for the symptoms of renal failure.


Using lithium and Toradol and lithium can lead to lithium toxicity, which should be closely monitored in patients using the combination of these two medications.

Antiepileptic drugs

Cases of seizures have been reported with combined use of antiepileptic drugs (carbamazepine and phenytoin) and Toradol


Using Toradol with methotrexate can increase the toxicity of methotrexate

Psychoactive drugs

When Toradol is taken by patients already using psychoactive drugs like fluoxetine, alprazolam, thiothixene hallucinations can occur in such patients.

Muscle Relaxants- Nondepolarizing

Using Toradol and nondepolarizing muscle relaxants leads to an interaction between ketorolac tromethamine those results in apnea.


Patients using Toradol and SSRIs can experience gastrointestinal bleeding so extra caution should be taken when you use SSRIs with Toradol.


The combination of Pentoxifylline and Toradol results in bleeding.

There are many other drugs that can interact with Toradol and here are some of them listed below

  • aliskiren
  • acetylsalicylic acid
  • apixaban
  • multivitamins
  • mesalamine
  • pemetrexed
  • prasugrel
  • bimatoprost
  • cholestyramine
  • sulfasalazine
  • tenofovir
  • tacrolimus
  • deferasirox
  • digoxin
  • vancomycin
  • heparin
  • vitamin E
  • venlafaxine
  • heparin
  • hydralazine
  • eplerenone
  • warfarin

If you are using any of the above medicines, discuss with your doctor/pharmacist. Depending on your medical condition your doctor might advise

  • you to stop using either of the medications
  • change either of the medication to some other medication
  • change the dose and frequency of either or both of the medications
  • or ask you to continue with the current schedule

A drug interaction doesn’t always mean that you need to stop using any one of the medications. You can discuss with your doctor about how the drug interactions and be or should be managed. Let your doctor know if you are using any prescription/non prescription, herbal medications.  Also let your doctor know if you are using any other supplements. Do not hesitate to share with your doctor if you are taking street drugs, smoking nicotine through cigarettes, drinking alcohol as these drugs and other things can affect the medication you have been prescribed.

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