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Hydrocortisone- A corticosteroid that treats many skin conditions too

Hydrocortisone is a corticosteroid that is used to treat severe allergies, multiple sclerosis, asthma, arthritis and various skin conditions. It prevents the tissues from reacting to inflammation. It also changes the response of our body to immune stimulation.

Avoid using Hydrocortisone if

  • If you have a fungal infection
  • you are allergic to a specific ingredient present in Hydrocortisone
  • you are using mifepristone

Some medical conditions can interact with Hydrocortisone. Speak to your doctor if the following medical conditions are applicable to you

  • If you are allergic to certain types of substances, food or medicines
  • Have a history of kidney or liver problems, overactive thyroid, high BP, oesophagus inflammation, stomach problems, heart attack, heart problems, bowel problems, bowel blockage, mood or mental problems gravis or ulcerative colitis.
  • If your live viral vaccination or any other vaccination is scheduled
  • if you are planning to become pregnant, if you are pregnant or you are  a nursing mother
  • if you are using any prescription/non prescription medicine, dietary supplement or herbal preparation

Dosing information

Normal Adult Dose – Adrenocortical Insufficiency

Acute Adrenal Gland Failure:
100 mg IV bolus, then 300 mg/day in split doses after every 8 hours

Or same like continuous dosing for about 48 hours.

When patient is stable, the dose can be changed to oral, 50 mg after every 8 hours for 6 doses,

Then adjust the dose to 30 – 50 mg per day

Usual Adult Dose – Anti-inflammatory

Oral, Intravenous or, Intramuscular: 15-240 mg  per day

Usual Adult Dose- Shock

200 mg/day by continuous intravenous dosing

Side effects- Major

More common

  • blurred vision
  • agitation
  • Aggression
  • blurred vision
  • anxiety
  • nervousness
  • weight gain
  • breathlessness
  • rattling or noisy breathing
  • headache
  • irritability
  • trouble speaking, walking or thinking

Drug Interactions

Discuss with your health care provider if you are using any other medications apart from Hydrocortisone. They can be illegal drugs, herbal, dietary, nutritional, dietary drugs especially

  • Aspirin
  • Arthritis medications
  • Cyclosporine
  • Estrogen
  • Digoxin
  • Theophylline
  • Phenytoin
  • Phenobarbital
  • Ketoconazole
  • Vitamins
  • Rifampin
  • Anticoagulants

You should also restrict the amount of alcohol you take while using oral Hydrocortisone especially if you take aspirin in large doses, take arthritis medicines or have a history of stomach ulcers.

Hydrocortisone and pregnancy

Since there are no evidences available that explain whether use of Hydrocortisone is safe or not during pregnancy, it is recommended that pregnant should avoid using Hydrocortisone during pregnancy. Check with your doctor to make sure if it is safe to use this medication while you are pregnant.

Hydrocortisone and breastfeeding

There are not adequate studies available to justify the use of Hydrocortisone during breast feeding, so breastfeeding moms should avoid using Hydrocortisone. Get in touch with your doctor to find out more.

Make sure you discuss about your medical conditions and the medicines you are using before you start using Hydrocortisone and take Hydrocortisone as recommended by the doctor.


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