Using Imipramine during pregnancy or breastfeeding

While some drugs are safe for use during pregnancy or breastfeeding, many antidepressants aren’t safe. Pregnant women and breastfeeding mothers should check with their doctors before using any antidepressant during their pregnancy or breastfeeding.

Imipramine and pregnancy

The studies conducted on Imipramine and pregnancy says that the medication does not cause any defects when given to pregnant animals. Though there are some reports that claim, there are chances of birth defects in human pregnancy, when the drug is used during pregnancy. Since there are no adequate studies available, you can check with your doctor if taking Imipramine is safe for you and your unborn baby. The doctor can determine the risks and benefits of the medication and prescribe you the right dosage accordingly.

In pregnant women use of Imipramine pamoate and Imipramine hydrochloride is not safe. This is based on certain studies conducted on animals and the study reports a few cases of birth defects in humans.

If you are pregnant and using Imipramine let your doctor know about your pregnancy and if the medication is necessary, your doctor can examine your current medical condition and decide whether using Imipramine during pregnancy is safe for you and your baby.

Imipramine and breastfeeding

Imipramine is secreted in breast milk in low amounts. Mothers should use Imipramine with extra caution while breastfeeding. You can check with your doctor for the risks and benefits of using Imipramine while breastfeeding. The doctor will prescribe you the drug only if the benefits are higher than the risks to your baby.

Mothers can also discontinue breastfeeding for some time while they are using Imipramine. According to the studies, very less amount of Imipramine was found in blood of babies who were breastfed. Studies also show that there were no harmful effects seen on the development of babies who were breastfed by mothers using Imipramine.

Before using Imipramine, you should discuss with your doctor if you can use Imipramine as everyone’s medical condition is different and your doctor can examine you and based on your current medical condition, he can suggest you whether to use Imipramine or not.

Some reports say that using Imipramine while breastfeeding can lead to drowsiness in baby. In case you notice drowsiness or a lot of weight loss, talk to your paediatrician and he can monitor the blood levels of your baby. Even mothers can stop using drug to see if baby’s health comes back to normal.

The levels of Imipramine in breast milk are low, but if the drug is used for a long term, there are chances that it can affect your baby’s health. Some mothers prefer stopping the drug during breastfeeding while other prefers low doses of Imipramine. You can also check with your doctor if he can replace Imipramine with other alternative medicines to treat depression. This can help you manage depression without causing harm to your baby. It is better to monitor your baby closely while taking Imipramine during breastfeeding and call your doctor immediately in case you notice unusual symptoms in your baby.

Using Imipramine can also lead to side effects

Using Imipramine bring in some side effects that you should know about. These side effects can be treated or prevented easily if they are identified in its early stages. Your doctor can help you know how to prevent or reduce the side effects safely while you are on Imipramine.

Major side effects of Imipramine that need immediate medical help

  • blurred vision
  • dry mouth
  • stomach or abdominal pain
  • cold sweats
  • dark urine
  • double vision
  • hearing loss
  • irritability
  • hostility
  • lethargy
  • hyperventilation
  • nightmares
  • restlessness
  • slow speech
  • sore throat
  • trouble sleeping
  • unusual behaviour
  • agitation
  • crawling, numbness, burning, prickling, itching or tingling feeling
  • chest discomfort or chest pain
  • confusion about time, identity or place
  • dribbling
  • light-headedness, fainting or dizziness while rising from a lying or sitting position
  • false beliefs
  • irregular, fast or pounding pulse or heart beat
  • decrease in frequency of urination
  • continuing buzzing, ringing noise in ears
  • hoarseness or cough
  • hearing, seeing or feeling things that doesn’t exist
  • feeling that others are controlling your behaviour or watching you
  • fever with/without chills
  • dry, flushed skin
  • general feeling of weakness or tiredness
  • inability to move facial, arms and leg muscles
  • side pain or lower back pain
  • muscle spasms
  • muscle trembling
  • muscle stiffness
  • purple or pinpointed red spots on skin
  • redness of arms, neck or face
  • swelling of hands, ankles, legs or face
  • uncontrolled face, back and neck movements
  • weakness in feet, hands, arms or legs
  • yellow skin or eyes

Symptoms of Overdose


  • clammy or cold skin
  • disorientation
  • bluish colour of palms, nail beds, skin, lips and fingernails.
  • weak or fast pulse
  • troubled breathing
  • decreased responsiveness or awareness
  • severe sleepiness
  • hallucinations
  • slow, shallow, fast or irregular breathing

Minor Side effects

Some side effects do not need medical attention as they disappear with time. Once your body gets used to the medication minor side effects disappear on their own. But if these side effects continue for a long and bother you, speak to your doctor as you need immediate medical attention.

Occurrence not known

  • black tongue
  • peculiar taste
  • severe sunburn
  • dilated, bigger or enlarged pupils
  • decreased ability or interest in sexual intercourse
  • difficulty with bowel movement
  • welt or hives
  • increased urge or urinating at night
  • increased eye sensitivity to light
  • enlargement of breasts
  • increase in sexual drive, ability, desire or performance
  • discoloration or redness of skin
  • swollen testicles
  • breast soreness and swelling in both males and females
  • excess flow of milk from breasts
  • waking at night to urinate
  • painful, tender or swollen lymph glands on the side of neck or face

Make sure you know about these possible side effects and contact your health care provider in case you notice any unexpected symptoms.



Treating depression and bedwetting with Imipramine

Imipramine is normally used to treat depression. It is also helpful in reducing bedwetting in children. Imipramine is an antidepressant (tricyclic) and works by enhancing certain chemicals present in the brain that helps boost your mood.
The generic name is Imipramine and brand name is Tofranil. Avoid using Imipramine if
1. You are allergic to any of the ingredient present in Imipramine
2. You have used MAOIs or linezolid in last 14 days.
3. You are regaining health after a heart attack
Important Information
Some medical conditions can interact with Imipramine. Speak to your doctor if you have any medical conditions like
1. If you are pregnant or planning to get pregnant or a lactating mother.
2. If you are using any non-prescription/prescription medicine, dietary supplement or herbal preparation
3. If you have a history of alcohol addiction or you consume alcohol
4. If you take thyroid medicine or had overactive thyroid in the past or having glaucoma, liver or kidney problems, heart problems seizures, diabetes, porphyria or problems urinating.
5. If you have a history of bipolar disorder, suicidal behaviour or thoughts, mental disorder or undergoing electroshock treatment/or if any surgery is scheduled.
6. If you are using any medicine that consists of methylene blue.
Make sure you read the label carefully and follow the instructions. Use Imipramine orally without food or with food. Check with your doctor if you can take Imipramine during bedtime to reduce possible side effects. To get the desired results it can take 1-3 weeks. Continue using Imipramine even if you are feeling better and do not miss any of Imipramine doses. In case you miss a dose, take the missed dose as soon as it strikes you. If it is time for your next dose, then do not take the missed dose and get back to your normal dosing schedule. Do not take two doses at one time.
Do not take alcohol with Imipramine as it can lead to blurred vision, dizziness and drowsiness. Use Imipramine with extra caution. Do not perform the tasks that are unsafe like driving as it needs extra alertness.
Discuss with your doctor before you consume alcohol or any other medicines with Imipramine.
Serotonnin syndrome is caused due to consumption of Imipramine. The risk is higher if you use Imipramine with other drugs like MAOIs and triptans. Symptoms include coma, hallucination, fever, confusion, tremor, irregular heartbeat, nausea, vomiting and excessive sweating.
Young adults, teenagers and children who use Imipramine are at higher risk of developing suicidal actions or thoughts. This can even be worse if the patient has a history of suicidal actions or thoughts. Get in touch with your health care provider if you notice worsened, new or sudden symptoms like restless, panic attacks, irritable behaviour, depressed moods, and unusual mood fluctuations.
Imipramine also makes you suffer from sunburns easily so avoid, sunlamps, sun or tanning booths till the time you know how your body responds to Imipramine.
Is Imipramine addictive?
It is not addictive. But once the treatment is stopped after a long period can lead to malaise, nausea and headache.

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