Oxycodone hydrochloride tablets are used to manage mild to severe pain in patients who need oral opioid analgesic treatment. The dose needs to be individually adjusted depending upon the patient’s response, severity of pain and patient size. If the severity of pain increases, if analgesia is not sufficient, if the patient is getting tolerant to medicine, a gradual increase in oxycodone dosage may be needed.
Patients who have not been prescribed opioid analgesics should begin with initial dose of Oxycodone hydrochloride tablets in range of 5-15 mg after every 4-6 hours as required for pain. The dose needs to be adjusted based on individual response of a patient to the starting dose of Oxycodone hydrochloride tablets. Patients suffering from chronic pain should be given around the clock dosage so that pain doesn’t occur again than managing pain after it occurs. This dose can be adjusted later to a tolerable analgesic level considering the side effects observed in patients.
To control chronic pain, which is severe in nature, Oxycodone hydrochloride tablets should be given on a regular and scheduled basis after every 4 to6 hours at very low doses that meets the sufficient analgesic requirement.
Like with any other powerful opioid, it is important to adjust the dosing schedule for every patient individually considering patient’s previous experience with analgesic treatment. Although it is not easy to list every possible condition that is crucial in selecting the initial dose of Oxycodone hydrochloride tablets, there are some points that can be considered to decide the initial dose and they are
- The daily dose, strength and features of a mixed antagonist/agonist or pure agonist the patient has been using previously.
- The reliability of respective strength estimate to calculate the required dose of Oxycodone.
- The level of opioid tolerance
- The medical status and general condition of the patient
- The stability between the adverse experiences and pain control
Over dosage of Oxycodone and its treatment
Symptoms and Signs
Acute overdose can be reflected by somnolence progressing to coma or stupor, respiratory depression, clammy or cold skin, skeletal muscle stiffness, constricted pupils, hypotension, bradycardia and even death.
To treat the overdose of Oxycodone hydrochloride tablets, main attention should be given to re-building of patient’s airway, establish and facilitate controlled ventilation. Supportive measures like vasopressors and oxygen should be used to deal with pulmonary edema or circulatory shock along with overdose as stated. Arrhythmias or cardiac arrest may also require defibrillation or cardiac massage.
The specific antidotes available for overdose are nalmefene, naloxone, narcotic antagonists etc., The action of Oxycodone is quite fast and in case of overdose, the patient should be kept under observation to track the symptoms of overdose and provide required treatment.
Gastric emptying is quite useful in flushing out the unabsorbed drug. In case you notice symptoms of overdose, call medical help immediately as if it is not treated in time can lead to life threatening complications. You should not ignore overdose symptoms as it needs immediate treatment.