Possible Oxycodone drug interactions elaborated

There are many drugs that can interact with Oxycodone. In order to use the Oxycodone drug, tell your doctor if you are using any other prescription, non prescription, nutritional, recreational, herbal dietary drugs you are using. The following drugs are some out of a plenty of other drugs that can interact with Oxycodone.

  • Antibiotics like erythromycin and clarithromycin
  • Antidepressants
  • Drugs for nausea, mental illness and anxiety
  • narcotic drugs
  • sleeping drugs
  • diuretics
  • tranquilizers
  • sedatives
  • MAOIs like selegine, phenelzine etc.,
  • muscle relaxants
  • Rifampin
  • Rifabutin
  • Phenytoin
  • Antihistamines
  • some HIV medicines like ritonavir, indinavir

Neuromuscular Blocking- Agents

Oxycodone increases the neuromuscular blocking activity of skeletal muscle relaxant and generates a high level of respiratory depression.

Mixed Antagonist/Agonist Opioid Analgesics

Antagonists/Agonist analgesics like butorphanol, nalburphine, pentazocine etc., should be given with caution to patients receiving or received a series of therapy with a natural opioid agonist analgesic like Oxycodone hydrochloride tablets. In such circumstances, mixed antagonist/agonist analgesics can decrease the analgesic effect of Oxycodone hydrochloride tablets or may trigger withdrawal symptoms in such patients.

CNS depressants

Patients who are given general anaesthetics, narcotic analgesics, tranquilizers, phenothiazines, sedative hypnotics or CNS depressants taking Oxycodone hydrochloride tablets simultaneously can experience additional CNS depression. Influential effects result in hypotension, respiratory depression, coma or profound sedation, if you take these drugs with Oxycodone hydrochloride tablets. In case a therapy including the combination of both is given, the dose of either of the agents needs to be reduced.


MAOIs escalate the effect of minimum one opioid drug that causes confusion, anxiety, coma or respiratory depression. Oxycodone hydrochloride tablets are not advised in case the patient has been taking MAOIs in past 14 days of treatment or after stopping the treatment.

Interaction between Oxycodone and Furosemide

Oxycodone and Furosemide can have additional effects in decreasing your blood pressure. You may notice dizziness, headache, and change in heart rate or pulse rate, fainting, light-headedness. These effects are noticed in initial stages of treatment, following an increase in dose or when the treatment is started again after a gap. Tell your doctor if these symptoms do not disappear after a couple of days or become bothersome. Avoid driving or operating heavy machinery till the time you know how the medication works for you. Be careful when rising from a lying or sitting position. Let your doctor know about any other medications that you are using like vitamins, minerals or herbs. Do not stop using the medications suddenly without speaking to your doctor.

Before you make any changes to the dose or Oxycodone, speak to your doctor. Drug interactions can affect how Oxycodone works for you; therefore it is necessary to let your doctor know about other drugs you are using. Your doctor can help you know which medications interact with Oxycodone so that you can get maximum benefit from Oxycodone and use drug with care. Do not take any decision regarding the dosage of any drug without discussing with your doctor.

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