leukemia

5 Most Painful Procedures

Luckily for everybody who lives in the 21st century, the days when a bottle of whiskey was considered a legitimate anesthetic during painful procedures, are long gone. Today, there is a wide array of local and general anesthetics that can be applied if you are to undergo some of these horribly painful procedures. At times, some of them are necessary, so here is a list of the worst ones.

Spinal Tap

This procedure is also called lumbar puncture. It means that a doctor inserts a hollow needle into the lumbar part of your spine and into the subarachnoid space in the spinal column. Once there, the doctor extracts the cerebral fluid. This procedure can be done diagnostically or as a part of therapy. The therapy involves injecting medicine directly into the fluid, rather than extracting it for analysis.

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Abdominal Hysterectomy

It is said that this procedure is the only one that comes close to childbirth in terms of pain. Abdominal Hysterectomy is a procedure of uterus removal. It can be total or partial. Abdominal hysterectomy is done by making an incision on your abdomen through which the uterus is removed. In some cases, cervix and ovaries are removed, as well. It is usually performed when it comes to aggressive, malignant changes to stop them from spreading. There is also the laparoscopic hysterectomy which is not nearly as painful. Discomfort after the abdominal one can last for weeks.

Bone Marrow Biopsy or Donation

This procedure is similar to the lumbar puncture. It is also performed with a hollow needle in order to extract the bone marrow fluid of a donor. It is usually taken from the top part of the back of a hip bone. The entire procedure lasts for about 30 minutes and there are a lot of anesthetics available to numb the sharp pain. Bone marrow can be used to diagnose certain types of cancer or leukemia, but this procedure is also used to donate bone marrow to people who are in dire need.

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Liposuction

During this procedure a hollow stainless steel tube is inserted in your body through a small incision. Once it reaches the deep fat layer, the fat gets sucked out of the body. The doctor will make several incisions in order to target certain places that contain more fat. The recovering period involves bruising, pain and swelling. Also, wearing compression bandages is required for a while until the swelling reduces and the body adapts to the new shape. While most people undergo this surgery for the esthetic reasons, there are some medical conditions that are treated by liposuction.

Tattoo Removal

While getting a tattoo is performed without anesthetics, tattoo removal needs to be done under local anesthesia since the procedure is far more painful. The entire process of getting rid of the tattoo is done with lasers. Since the pigment inserted by tattooing is too big for the skin to throw it out through its normal healing process, it is important to break it down into smaller pieces. That is just what the laser does. It heats the ink under the skin until it breaks down. With proper anesthetic, you can have a painless tattoo removal process.  

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All these procedures would be close to unbearable if there wasn’t the modern miracle of local and general anesthesia. Either way, some of these procedures are needed to save your or somebody else’s life. Others are just elective and they are about your body image. Therefore, it is up to you whether the pain and the recovery period are worth the benefits that you get from such procedures.

Gleevec is under patent in the U.S., but not in India

Gleevec is under patent in the U.S., but not in India. Accordingly, Novartis, its Swiss-based manufacturer, may prevent competitors from making and selling lower-cost versions of the drug in the U.S., but not in India.

Rejecting the Gleevec patent application is not the only step that the Indian government has taken to circumvent patents on cancer drugs. Last year, India issued a compulsory license on Nexavar, a late-stage kidney and liver cancer treatment, enabling a local drug firm to produce a generic version of this medicine without the permission of Bayer, the patent holder. India has recently announced plans to grant compulsory licenses on another leukemia drug and two breast cancer therapies.

What is Gleevec?

Gleevec (imatinib) interferes with the growth of some cancer cells.

Gleevec is used to treat certain types of leukemia (blood cancer), bone marrow disorders, and skin cancer, or certain tumors of the stomach and digestive system.

Gleevec may also be used for purposes not listed in this medication guide.

Important information

Gleevec can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

Gleevec may increase the risk of fluid retention or heart problems. Tell your doctor if you have swelling or rapid weight gain, shortness of breath, fast or slow heart rate, weak pulse, or fainting.

Gleevec side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Gleevec: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fever, chills, body aches, flu symptoms;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • swelling, rapid weight gain, feeling short of breath (even with mild exertion);
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • lower back pain, blood in your urine, little or no urinating;
  • numbness or tingly feeling around your mouth;
  • muscle weakness, tightness, or contraction, overactive reflexes;
  • fast or slow heart rate, weak pulse, confusion, fainting; or
  • severe skin reaction — fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

The big price difference of Gleevec between china and India makes Chinese Cancer Patient Criminals

After businessman Lu Yong was charged with “the sale of fake drugs” and “impairing credit card administration”, the case once again set off debates over unlicensed overseas anti-tumor medicines.

In contrast with patented drugs sold for higher prices, partially resulting from huge R&D expenditure by initial developers, the compulsory license practice enabled an Indian generic version to be more affordable. In China, there is also such a stipulation in patent law, which has never been resorted to.

Gleevec
Gleevec

The 46-year-old owner of a textile export company in Wuxi, Jiangsu province, Lu helped buy Indian medicines, which are unlicensed in China, via credit cards that turned out to be illegal.

Under the current legal system, drugs that have not been given the green light by related authorities are considered fake, even if they are effective, prosecutor Luo Jian, who is dealing with the case, told Beijing Times.

People who provide accounts for the sale of fake drugs will be treated as accomplices, according to the law, Luo said.

Lu himself was diagnosed with chronic myeloid leukemia in 2002 and began to take Gleevec, developed by Swiss pharmaceutical giant Novartis for use in the treatment of multiple cancers.

The anti-tumor drug recommended by his doctor was priced around 23,500 yuan ($3,777) per box at that time and he needed to take one box a month.

As the medicine is not covered by the national medical insurance system, he told Chinese Business View that he spent 600,000 to 700,000 yuan on his treatment in the first two years after his diagnosis and was almost broke.

In 2004, Lu began to turn to Gleevec’s Indian version, Veenat, which had a similar effect yet cost much less, 3,000 yuan, if bought directly from India. He shared his find with other leukemia patients in support groups at social network platform QQ. As a result, more than 1,000 members of the groups followed suit.

Complicated procedures that involve filing various documents in English for the shipments remained a “torture” for many of these new buyers. So Lu served as an interpreter for them, free of charge.

The price of Veenat continued to fall over the years, because of growing group purchases. The cost, including mail charges, had dropped to around 200 yuan by September 2013, Lu said.

To tap into the huge underground market, the Indian company opened bank accounts in China to facilitate remittance yet faced frequent problems due to restrictions and technical issues in transnational payments.

The company asked Lu, one of their earliest Chinese buyers, to use his own account as a bridge, he told media.

They had previously used accounts belonging to two patients in Yunnan province, through which Lu and others suffering from leukemia remitted payments for their medicines from India. But the account owners quit as the volume of trade grew because they were afraid of getting into trouble.

Lu took over the transfer role. He bought credit cards at an online shop in 2012 to remit payments for more than 1,000 patients a month. He said he didn’t realize that the shop was “an illegal group specializing in credit card trade” until he was caught by police in November 2013.

He was prosecuted in Yuanjiang, Hunan province, in July 2014. The court was scheduled to hear the case in late November but it was postponed because of his health.

“I’ve just told those that are sick as me the medicine that can maintain our lives,” he told the Oriental Morning Post. “They didn’t buy medicines from me and I earned no difference or charged any fees.”

Chinese Business View quoted him as saying: “If I were taken back in time, I would do the same. Our national policies cannot cover every patient. What I did is complementary to the shortcomings of the policies.”

For him, the biggest benefit from providing his accounts might be the free drugs provided to him by the Indian company, as they had done with the previous account providers. Yet Lu said the exemption was not a big deal for him.

Prosecutor Luo said: “Law has its own bottom line. It is out of the question to give him an immunity from criminal liabilities just because he did it for others. Otherwise he would be followed and the law would be pointless.”

According to the latest judicial interpretation by the Supreme Court released in November, the sale of a small number of unlicensed overseas medicines that do not damage or delay treatment is not considered a crime.

There is some humanity in the policy, Liu Guiming, chief-editor of Democracy and Law magazine, told The Paper.

It takes care of individual cases. When there is a patient in need of such medicine at home, the Indian drug is an option for consideration, Liu said.

Yet for cancer patients that need to take anti-tumor drugs in the long-term, it is easy to cross the line.

Lu said Gleevec in China is probably sold at the highest price in the world, much more than the $2,200 it costs in the United States. He called on foundations to help resolve the medical bills for cancer patients and suggested governments negotiate with companies to cut prices.

He said he hoped more anti-tumor drugs would be covered by national medical insurance. However Xiao Zesheng, a law professor at Nanjing University, told The Paper that paying too high prices for anti-tumor medicines will damage others’ interests and is unfair to them. “The key is the high prices,” he said.