What happens when Protriptyline is used with some other drugs?

When Protriptyline is used with some other drugs, it can lead to adverse symptoms that need immediate medical attention. This article will mention some drugs that interact with Protriptyline and their effects, though the list is endless.

When Protriptyline is used with sympatho-mimetic drugs and anticholinergic agents including combined local anaesthetics with epinephrine, careful dosage adjustment and careful supervision is necessary. Using Protriptyline with neuroleptic drugs or anticholinergic agents lead to Hyperpyrexia, especially when used during hot weather.

Protriptyline and Cimetidine

Cimetidine when taken in combination with Protriptyline can reduce the hepatic metabolism of Protriptyline thereby delaying removal and increasing constant concentration of antidepressants. It has been reported that using cimetidine simultaneously with Protriptyline can increase the plasma levels of Protriptyline and can also increases the severity and frequency of possible side effects, especially anticholinergic.

Protriptyline and modafinil

Before starting with Protriptyline, let your doctor know that you are using modafinil. The combination of these two medications can cause

  • dry mouth
  • sedation
  • constipation
  • blurred vision
  • urinary retention

If you are using these two medications together and notice any of the symptoms above, seek medical help immediately. You doctor might suggest a dose adjustment if you are using the two medications together. It is very important to inform your doctor about other medicines that you are using like herbs, vitamins etc., do not stop taking any of the medications without your doctor’s advice.

Protriptyline and Butalbital

Taking Protriptyline with butalbital can affect the efficacy of one of the medications. This can be more dangerous if you are taking butalbital to control seizures. Speak to your doctor if you are using these medications together. Your doctor might suggest you a dose adjustment or some special tests so that you can use the medications safely. . It is very important to inform your doctor about other medicines that you are using like herbs, or vitamins. Do not stop taking any of the medications without your doctor’s advice.

Protriptyline and Pregabalin

Taking Protriptyline and Pregabalin together can increase some side effects like

  • drowsiness
  • difficulty in concentrating
  • dizziness
  • confusion

Elderly people often experience impairment in judgement, thinking and motor coordination. Do not consume alcohol or get involved in activities that need you to be extra alert or operating heavy machinery till the time you are not sure how your body responds to the medication. You can discuss with your doctor if you have any doubts or concerns. Also discuss with your doctor if you are using any other medications like herbs or vitamins. Avoid halting the use of any medications without your doctor’s consent.

Taking Protriptyline with some drugs can slow your breathing or make you feel sleepy. Also check with your doctor if you are using Protriptyline with a narcotic pain medicine, sleeping pill, and muscle relaxer, medicine for seizures, depression or anxiety.

If you are using Protriptyline and taken an SSRI in last 5 weeks let your doctor know about it. The SSRIs can be sertraine, fluoxetine, fluvoxamine etc.

Leave a Reply