Morphine dosage information explained

The Morphine dosage information mentioned below can be considered as some suggested doses derived from clinical decisions and again the doses differ based on needs of each individual and his/her medical condition. Always approach your doctor for the right dosage as he can examine your medical conditions and suggest the right dosage of Morphine.

Normal Adult dose – Pain

Tablets- Immediate release

Opioid naïve

Initial dose: 15-30mg to be taken orally after every four hours as required.

Oral Solution- Opioid Naïve

Initial dose: 10-20mg to be taken orally after every 4 hours as required.

Notes

Oral solutions

Opioid naïve patients should be started with the following strengths

10mg per 5ML or 20mg per 5 ML

Patients who are tolerant to opioid and are titrated to a fixed analgesic program using low doses of Morphine can be started on 100mg per 5ML

 

Extended release- oral

Different products (extended release) are not bioequivalent. The product information for each product should be considered before the dosage is been prescribed and accordingly the dosage adjustment should be done for each individual patient.

Opioid tolerant

Dose- to be taken 1-2 times in a day based on the product prescribed

Opioid Naïve

Initial dose

30mg to be taken orally after every 24 hours

Suppository

10-25mg – to be taken rectally after every 4 hours as required.

Subcutaneous/IM

Initial dose:

10mg after every 4 hours as required

Dose range

5-20mg after every 4 hours as required

IV

As preanesthetic and for pain relief

Initial Dose: 4-10mg after every 4 hours managed slowly over 4-5 minutes

Dose range: 5-15 mg

Dose range (Daily): 12-120mg

Alternate dose: 2-10mg for 70 kg of body weight

Dose Adjustments

The dosing schedule of Morphine should be adjusted for every patient individually, considering previous analgesic treatment information. Consider the following before selecting the initial dose

  1. Different preparations of Morphine are not bioequivalent. Before shifting a patient from one form of morphine to another, consult local protocol or product labeling.
  2. The complete daily dose and opioid strength the patient had taken previously.
  3. The level of patient’s opioid tolerance
  4. The medical status and general condition of the patient
  5. Severity and type of pain
  6. Concurrent medications
  7. Risk factors related to diversion, drug abuse, addiction, past history of addiction, abuse or diversion.

In case of cancer patients, rescue doses of oral formulations of immediate release form may be required.

Morphine – Overdose – Treatment

Morphine overdose takes place when a person accidently or intentionally takes morphine in excess. Morphine is a very strong painkiller. In case you notice overdose symptoms call poison control center immediately. In case of overdose the person gets treatments like

  • activated charcoal
  • urine or blood tests are conducted
  • laxative
  • chest X-ray
  • fluids via a vein
  • Naloxone – a medicine used to alter the effect of poison.
  • Airway support given like breathing machine, breathing tube via mouth including oxygen.

In case of overdose if the person stops breathing can die if he doesn’t get medical attention in time.

Leave a Reply